nca | R Documentation |

Perform an NCA based on a NONMEM-style dataset

nca( data = NULL, dose = 100, tau = 24, method = c("log_linear", "log_log", "linear"), scale = list(auc = 1, conc = 1), dv_min = 0.001, t_inf = NULL, fit_samples = NULL, weights = NULL, extend = TRUE, has_baseline = TRUE, route = c("iv", "oral", "im", "sc") )

`data` |
data.frame with time and dv columns |

`dose` |
dose amount |

`tau` |
dosing frequency, default is 24. |

`method` |
'linear', 'log_linear' (default), or 'log_log' |

`scale` |
list with scaling for auc and concentration ('conc') |

`dv_min` |
minimum concentrations, lower observations will be set to this value |

`t_inf` |
infusion time, defaults to 0 |

`fit_samples` |
vector of sample indexes used in fit to calculate elimination rate, e.g. 'c(3,4,5)'. If not specified (default), it will evaluate which of the last n samples shows the largest adjusted R^2 when log-transformed data is fitted using linear regression, and use those samples in the estimation of the elimination rate. |

`weights` |
vector of weights to be used in linear regression (same size as specified concentration data), or function with concentration as argument. |

`extend` |
perform an 'extended' NCA, i.e. for the calculation of the AUCs, back-extend to the expected true Cmax to also include that area. |

`has_baseline` |
does the included data include a baseline? If 'FALSE', baseline is set to zero. |

`route` |
administration route, 'iv' (intravenous, default), 'oral', 'sc' (sub-cutaneous), or 'im' (intra-muscular). |

Returns a list of three lists:

`pk`

Lists pk parameters.

`kel`

: elimination constant`t_12`

: half-life`v`

: distribution volume`cl`

: clearance

`descriptive`

Lists exposure parameters.

`cav_t`

: the average concentration between the first observation and the last observation without extrapolating to tau`cav_tau`

: the average concentration from 0 to tau`cmin`

: the extrapolated concentration at`time = tau`

`c_max_true`

: only available if`extend = TRUE`

, the extrapolated peak concentration`c_max`

: only available if`extend = FALSE`

, the observed maximum concentration`auc_inf`

: the extrapolated AUC as time goes to infinity`auc_24`

: the extrapolated AUC after 24 hours, provided no further doses are administered`auc_tau`

: the extrapolated AUC at the end of the dosing interval`auc_t`

: the AUC at the time of the last observation

`settings`

Lists dosing information.

`dose`

: dose quantity`tau`

: dosing interval

data <- data.frame(time = c(0, 2, 4, 6, 8, 12, 16), dv = c(0, 10, 14, 11, 9, 5, 1.5)) nca(data, t_inf = 2)

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