pk_2cmt_bolus_dose_from_cmax: Calculate dose to achieve steady state Cmax for...

In clinPK: Clinical Pharmacokinetics Toolkit

Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state

Description

Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state

Usage

pk_2cmt_bolus_dose_from_cmax(
  cmax = 1,
  tau = 12,
  CL = 3,
  V = 30,
  Q = 2,
  V2 = 20
)

Arguments

cmax	desired trough concentration
tau	dosing interval
CL	clearance
V	volume of distribution
Q	inter-compartimental clearance
V2	volume of peripheral compartment

Examples

dos <- pk_2cmt_bolus_dose_from_cmax(
  cmax = 10, tau = 12,
  CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)

clinPK documentation built on May 29, 2024, 3:50 a.m.