gxe.coh: Estimation of gene-environment interaction on the additive...

In clinUtiDNA: Clinical Utility of DNA Testing

Description

Estimation of gene-environment interaction on the additive scale for cohort data

Usage

gxe.coh(aff, unaff)

Arguments

aff	a vector containing numbers affected individuals observed in the gene environment groups <G=0,E=0>, <G=1,E=0>, <G=0,E=1> and <G=1,E=1>
unaff	a vector containing numbers of unaffected individuals observed in the gene environment groups <G=0,E=0>, <G=1,E=0>, <G=0,E=1> and <G=1,E=1>

Details

see Nguyen et al. 2013

Value

GxE.coh

a list containing the interaction estimate, the corresponding variance and the boundaries of the 95% of the confidence interval

Author(s)

Thuy Trang Nguyen

References

Making Medical Decisions in Dependence of Genetic Background: Estimation of the Utility of DNA Testing in Clinical, Pharmaco-Epidemiological or Genetic Studies. Nguyen TT, Schaefer H, Timmesfeld N. Genet Epidemiol. 2013 Apr 4. doi: 10.1002/gepi.21701

See Also

gxe.cc, utility.coh, utility.cc

Examples

## Parameter initialisation
aff <-  c(150,24,135,39)
unaff <- c(544,111,393,63)
## Calculation of the interaction effect
gxe.coh(aff,unaff) 

clinUtiDNA documentation built on May 2, 2019, 9:27 a.m.