Calculation of the utility index for cohort data

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Description

Calculation of the the utility index for cohort data

Usage

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utility.coh(aff, unaff)

Arguments

aff

a vector containing numbers affected individuals observed in the gene environment groups <G=0,E=0>, <G=1,E=0>, <G=0,E=1> and <G=1,E=1>

unaff

a vector containing numbers unaffected individuals observed in the gene environment groups <G=0,E=0>, <G=1,E=0>, <G=0,E=1> and <G=1,E=1>

Details

see Nguyen et al. 2013

Value

Utility.coh

a list containing the utility estimate, the corresponding variance and the boundaries of the 95% of the confidence interval

Author(s)

Thuy Trang Nguyen

References

Making Medical Decisions in Dependence of Genetic Background: Estimation of the Utility of DNA Testing in Clinical, Pharmaco-Epidemiological or Genetic Studies. Nguyen TT, Schaefer H, Timmesfeld N. Genet Epidemiol. 2013 Apr 4. doi: 10.1002/gepi.21701

See Also

gxe.cc, gxe.coh, utility.cc

Examples

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## Parameter initialisation
aff <-  c(150,24,135,39)
unaff <- c(544,111,393,63)
## Calculation of the utility index
utility.coh(aff,unaff)