twostage.inference | R Documentation |
Calculates the p-value, UMVUE and CI for the data from a study using a two stage design for response.
twostage.inference(x, r1, n1, n, pu, alpha=0.05)
x |
number of responses observed at the end of the study |
r1 |
first stage threshold to declare treatment undesirable |
n1 |
first stage sample size |
n |
total sample size |
pu |
unacceptable response rate (null hypothesis) |
alpha |
the confidence level. For consistency with the design use the same value from the design. (default is 0.05) |
twostage.inference returns the UMVUE (Jung & Kim, 2004), p-value and CI (Koyama & Chen, 2008). The CI has confidence level 1-2*alpha and the one-sided (1-alpha) interval consistent with the design is obtained by changing the upper confidence limit (UCL) to 1.
Jung SH and Kim KM. (2004). On the estimation of the binomial probability in multistage clinical trials. Statistics in Medicine 23, 881-896.
Koyama T and Chen H. (2008). Proper inference from Simon's two-stage designs. Statistics in Medicine 27, 3145-3154.
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