crmPack: Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Package details

AuthorDaniel Sabanes Bove [aut, cre], Wai Yin Yeung [aut], Giuseppe Palermo [aut], Thomas Jaki [aut]
MaintainerDaniel Sabanes Bove <daniel.sabanes_bove@roche.com>
LicenseGPL (>= 2)
Version1.0.3
URL https://github.com/roche/crmPack
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("crmPack")

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crmPack documentation built on Sept. 3, 2022, 1:05 a.m.