crmPack: Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Author
Daniel Sabanes Bove <sabanesd@roche.com>, Wai Yin Yeung <winnie.yeung@roche.com>, Giuseppe Palermo <giuseppe.palermo@roche.com>, Thomas Jaki <jaki.thomas@gmail.com>
Date of publication
2016-07-16 23:06:48
Maintainer
Daniel Sabanes Bove <sabanesd@roche.com>
License
GPL (>= 2)
Version
0.2.0

View on CRAN

Man pages

AllModels-class
Class for All models This is a class where all models...
and-StoppingAll-Stopping-method
The method combining a stopping list and an atomic
and-Stopping-StoppingAll-method
The method combining an atomic and a stopping list
and-Stopping-Stopping-method
The method combining two atomic stopping rules
approximate
Approximate posterior with (log) normal distribution
as.list-GeneralData-method
as.list method for the "GeneralData" class
biomLevel
Compute the biomarker level for a given dose, given model and...
CohortSize-class
The virtual class for cohort sizes
CohortSizeConst
Initialization function for "CohortSizeConst"
CohortSizeConst-class
Constant cohort size
CohortSizeDLT
Initialization function for "CohortSizeDLT"
CohortSizeDLT-class
Cohort size based on number of DLTs
CohortSizeMax
Initialization function for "CohortSizeMax"
CohortSizeMax-class
Size based on maximum of multiple cohort size rules
CohortSizeMin
Initialization function for "CohortSizeMin"
CohortSizeMin-class
Size based on minimum of multiple cohort size rules
CohortSizeParts
Initialization function for "CohortSizeParts"
CohortSizeParts-class
Cohort size based on the parts
CohortSizeRange
Initialization function for "CohortSizeRange"
CohortSizeRange-class
Cohort size based on dose range
crmPackExample
Open the example pdf for crmPack
crmPackHelp
Open the browser with help pages for crmPack
crmPack-package
Object-oriented implementation of CRM designs
Data
Initialization function for the "Data" class
Data-class
Class for the data input
DataDual
Initialization function for the "DataDual" class
DataDual-class
Class for the dual endpoint data input
DataMixture
Initialization function for the "DataMixture" class
DataMixture-class
Class for the data with mixture sharing
DataParts
Initialization function for the "DataParts" class
DataParts-class
Class for the data with two study parts
Design
Initialization function for "Design"
Design-class
Class for the CRM design
dinvGamma
Compute the density of Inverse gamma distribution
dose
Compute the doses for a given probability, given model and...
DualDesign
Initialization function for "DualDesign"
DualDesign-class
Class for the dual-endpoint CRM design
DualEndpoint
Initialization function for the "DualEndpoint" class
DualEndpointBeta
Initialization function for the "DualEndpointBeta" class
DualEndpointBeta-class
Dual endpoint model with beta function for dose-biomarker...
DualEndpoint-class
General class for the dual endpoint model
DualEndpointEmax
Initialization function for the "DualEndpointEmax" class
DualEndpointEmax-class
Dual endpoint model with emax function for dose-biomarker...
DualEndpointOld-class
Dual endpoint model
DualEndpointRW
Initialization function for the "DualEndpointRW" class
DualEndpointRW-class
Dual endpoint model with RW prior for biomarker
DualResponsesDesign
Initialization function for 'DualResponsesDesign"
DualResponsesDesign-class
This is a class of design based on DLE responses using the...
DualResponsesSamplesDesign
Initialization function for 'DualResponsesSamplesDesign"
DualResponsesSamplesDesign-class
This is a class of design based on DLE responses using the...
DualSimulations
Initialization function for "DualSimulations"
DualSimulations-class
Class for the simulations output from dual-endpoint model...
DualSimulationsSummary-class
Class for the summary of dual-endpoint simulations output
EffFlexi
Initialization function for the "EffFlexi" class
EffFlexi-class
Class for the efficacy model in flexible form for prior...
Effloglog
Initialization function for the "Effloglog" class
Effloglog-class
Class for the linear log-log efficacy model using pseudo data...
examine
Obtain hypothetical trial course table for a design
ExpEff
Compute the expected efficacy based on a given dose, a given...
fit
Fit method for the Samples class
fitGain
Get the fiited values for the gain values at all dose levels...
gain
Compute the gain value with a given dose level, given a...
GeneralData-class
Class for general data input
GeneralModel-class
No Intitialization function for this General class for model...
GeneralSimulations
Initialization function for "GeneralSimulations"
GeneralSimulations-class
General class for the simulations output
GeneralSimulationsSummary-class
Class for the summary of general simulations output
getEff
Extracting efficacy responses for subjects without or with a...
getMinInfBeta
Get the minimal informative unimodal beta distribution
getResultList
Helper function to obtain simulation results list
get-Samples-character-method
Get specific parameter samples and produce a data.frame
Increments-class
The virtual class for controlling increments
IncrementsRelative
Initialization function for "IncrementsRelative"
IncrementsRelative-class
Increments control based on relative differences in intervals
IncrementsRelativeDLT
Initialization function for "IncrementsRelativeDLT"
IncrementsRelativeDLT-class
Increments control based on relative differences in terms of...
IncrementsRelativeParts
Initialization function for "IncrementsRelativeParts"
IncrementsRelativeParts-class
Increments control based on relative differences in...
initialize-DualEndpointOld-method
Initialization method for the "DualEndpointOld" class
is.bool
Predicate checking for a boolean option
is.probability
Predicate checking for a probability
is.probRange
Predicate checking for a probability range
is.scalar
Checking for scalar
is.wholenumber
checks for whole numbers (integers)
joinBodies
Helper function to join two function bodies
joinModels
Helper function to join two BUGS models
LogisticIndepBeta
Intialization function for "LogisticIndepBeta" class
LogisticIndepBeta-class
No initialization function Standard logistic model with prior...
LogisticKadane
Initialization function for the "LogisticKadane" class
LogisticKadane-class
Reparametrized logistic model
LogisticLogNormal
Initialization function for the "LogisticLogNormal" class
LogisticLogNormal-class
Standard logistic model with bivariate (log) normal prior
LogisticLogNormalMixture
Initialization function for the "LogisticLogNormalMixture"...
LogisticLogNormalMixture-class
Standard logistic model with online mixture of two bivariate...
LogisticLogNormalSub
Initialization function for the "LogisticLogNormalSub" class
LogisticLogNormalSub-class
Standard logistic model with bivariate (log) normal prior...
LogisticNormal
Initialization function for the "LogisticNormal" class
LogisticNormal-class
Standard logistic model with bivariate normal prior
LogisticNormalFixedMixture
Initialization function for the "LogisticNormalFixedMixture"...
LogisticNormalFixedMixture-class
Standard logistic model with fixed mixture of multiple...
LogisticNormalMixture
Initialization function for the "LogisticNormalMixture" class
LogisticNormalMixture-class
Standard logistic model with flexible mixture of two...
logit
Shorthand for logit function
maxDose
Determine the maximum possible next dose
maxSize
"MAX" combination of cohort size rules
mcmc
Obtain posterior samples for all model parameters
McmcOptions
Initialization function for the "McmcOptions" class
McmcOptions-class
Class for the three canonical MCMC options
MinimalInformative
Construct a minimally informative prior
minSize
"MIN" combination of cohort size rules
Model-class
Class for the model input
ModelEff-class
No Initialization function class for Efficacy models using...
ModelPseudo-class
Class of models using expressing their prior in form of...
ModelTox-class
No intialization function Class for DLE models using pseudo...
multiplot
Multiple plot function
myBarplot
Convenience function to make barplots of percentages
nextBest
Find the next best dose
NextBest-class
The virtual class for finding next best dose
NextBestDualEndpoint
Initialization function for "NextBestDualEndpoint"
NextBestDualEndpoint-class
The class with the input for finding the next dose based on...
NextBestMaxGain
Initialization function for the class 'NextBestMaxGain'
NextBestMaxGain-class
Next best dose with maximum gain value based on a pseudo DLE...
NextBestMaxGainSamples
Initialization function for class "NextBestMaxGainSamples"
NextBestMaxGainSamples-class
Next best dose with maximum gain value based on a pseudo DLE...
NextBestMTD
Initialization function for class "NextBestMTD"
NextBestMTD-class
The class with the input for finding the next best MTD...
NextBestNCRM
Initialization function for "NextBestNCRM"
NextBestNCRM-class
The class with the input for finding the next dose in target...
NextBestTD
Initialization function for the class "NextBestTD"
NextBestTD-class
Next best dose based on Pseudo DLE model without sample
NextBestTDsamples
Initialization function for class "NextBestTDsamples"
NextBestTDsamples-class
Next best dose based on Pseudo DLE Model with samples
NextBestThreePlusThree
Initialization function for "NextBestThreePlusThree"
NextBestThreePlusThree-class
The class with the input for finding the next dose in target...
noOverlap
Check overlap of two character vectors
or-StoppingAny-Stopping
The method combining an atomic and a stopping list
or-Stopping-Stopping
The method combining two atomic stopping rules
or-Stopping-StoppingAny
The method combining a stopping list and an atomic
pinvGamma
Compute the distribution function of Inverse gamma...
plot-DataDual-missing-method
Plot method for the "DataDual" class
plot-DataDual-ModelEff-method
Plot of the fitted dose-efficacy based with a given pseudo...
plot-Data-missing-method
Plot method for the "Data" class
plot-Data-ModelTox-method
Plot of the fitted dose-tox based with a given pseudo DLE...
plotDualResponses
Plot of the DLE and efficacy curve side by side given a DLE...
plot-DualSimulations-missing-method
Plot dual-endpoint simulations
plot-DualSimulationsSummary-missing-method
Plot summaries of the dual-endpoint design simulations
plotGain
Plot the gain curve in addition with the dose-DLE and...
plot-GeneralSimulations-missing-method
Plot simulations
plot-GeneralSimulationsSummary-missing-method
Graphical display of the general simulation summary
plot.gtable
Plots gtable objects
plot-PseudoDualFlexiSimulations-missing-method
This plot method can be applied to...
plot-PseudoDualSimulations-missing-method
Plot simulations
plot-PseudoDualSimulationsSummary-missing-method
Plot the summary of Pseudo Dual Simulations summary
plot-PseudoSimulationsSummary-missing-method
Plot summaries of the pseudo simulations
plot-Samples-DualEndpoint-method
Plotting dose-toxicity and dose-biomarker model fits
plot-Samples-ModelEff-method
Plot the fitted dose-effcacy curve using a model from...
plot-Samples-Model-method
Plotting dose-toxicity model fits
plot-Samples-ModelTox-method
Plot the fitted dose-DLE curve using a 'ModelTox' class model...
plot-SimulationsSummary-missing-method
Plot summaries of the model-based design simulations
printVignette
Taken from utils package (print.vignette)
prob
Compute the probability for a given dose, given model and...
PseudoDualFlexiSimulations
Initialization function for 'PseudoDualFlexiSimulations'...
PseudoDualFlexiSimulations-class
This is a class which captures the trial simulations design...
PseudoDualSimulations
Initialization function for 'DualPseudoSimulations' class
PseudoDualSimulations-class
This is a class which captures the trial simulations design...
PseudoDualSimulationsSummary-class
Class for the summary of the dual responses simulations using...
PseudoSimulations
Initialization function of the 'PseudoSimulations' class
PseudoSimulations-class
This is a class which captures the trial simulations from...
PseudoSimulationsSummary-class
Class for the summary of pseudo-models simulations output
qinvGamma
Compute the quantile function of Inverse gamma distribution
Quantiles2LogisticNormal
Convert prior quantiles (lower, median, upper) to logistic...
Report
A Reference Class to represent sequentially updated reporting...
rinvGamma
The random generation of the Inverse gamma distribution
RuleDesign
Initialization function for "RuleDesign"
RuleDesign-class
Class for rule-based designs
safeInteger
Safe conversion to integer vector
Samples
Initialization function for "Samples"
Samples-class
Class for the MCMC output
sampleSize
Compute the number of samples for a given MCMC options triple
saveSample
Determine if we should save this sample
setSeed
Helper function to set and save the RNG seed
show-DualSimulationsSummary-method
Show the summary of the dual-endpoint simulations
show-GeneralSimulationsSummary-method
Show the summary of the simulations
show-PseudoDualSimulationsSummary-method
Show the summary of Pseudo Dual simulations summary
show-PseudoSimulationsSummary-method
Show the summary of the simulations
show-SimulationsSummary-method
Show the summary of the simulations
simulate-Design-method
Simulate outcomes from a CRM design
simulate-DualDesign-method
Simulate outcomes from a dual-endpoint design
simulate-DualResponsesDesign-method
This is a methods to simulate dose escalation procedure using...
simulate-DualResponsesSamplesDesign-method
This is a methods to simulate dose escalation procedure using...
simulate-RuleDesign-method
Simulate outcomes from a rule-based design
simulate-TDDesign-method
This is a methods to simulate dose escalation procedure only...
simulate-TDsamplesDesign-method
This is a methods to simulate dose escalation procedure only...
Simulations
Initialization function for the "Simulations" class
Simulations-class
Class for the simulations output from model based designs
SimulationsSummary-class
Class for the summary of model-based simulations output
size
Determine the size of the next cohort
StoppingAll
Initialization function for "StoppingAll"
StoppingAll-class
Stop based on fullfillment of all multiple stopping rules
StoppingAny
Initialization function for "StoppingAny"
StoppingAny-class
Stop based on fullfillment of any stopping rule
Stopping-class
The virtual class for stopping rules
StoppingCohortsNearDose
Initialization function for "StoppingCohortsNearDose"
StoppingCohortsNearDose-class
Stop based on number of cohorts near to next best dose
StoppingGstarCIRatio
Initialization function for "StoppingGstarCIRatio"
StoppingGstarCIRatio-class
Stop based on a target ratio, the ratio of the upper to the...
StoppingHighestDose
Initialization function for "StoppingHighestDose"
StoppingHighestDose-class
Stop when the highest dose is reached
StoppingList
Initialization function for "StoppingList"
StoppingList-class
Stop based on multiple stopping rules
StoppingMinCohorts
Initialization function for "StoppingMinCohorts"
StoppingMinCohorts-class
Stop based on minimum number of cohorts
StoppingMinPatients
Initialization function for "StoppingMinPatients"
StoppingMinPatients-class
Stop based on minimum number of patients
StoppingMTDdistribution
Initialization function for "StoppingMTDdistribution"
StoppingMTDdistribution-class
Stop based on MTD distribution
StoppingPatientsNearDose
Initialization function for "StoppingPatientsNearDose"
StoppingPatientsNearDose-class
Stop based on number of patients near to next best dose
StoppingTargetBiomarker
Initialization function for "StoppingTargetBiomarker"
StoppingTargetBiomarker-class
Stop based on probability of target biomarker
StoppingTargetProb
Initialization function for "StoppingTargetProb"
StoppingTargetProb-class
Stop based on probability of target tox interval
StoppingTDCIRatio
Initialization function for "StoppingTDCIRatio"
StoppingTDCIRatio-class
Stop based on a target ratio, the ratio of the upper to the...
stopTrial
Stop the trial?
summary-DualSimulations-method
Summarize the dual-endpoint design simulations, relative to...
summary-GeneralSimulations-method
Summarize the simulations, relative to a given truth
summary-PseudoDualFlexiSimulations-method
Summary for Pseudo Dual responses simulations given a pseudo...
summary-PseudoDualSimulations-method
Summary for Pseudo Dual responses simulations, relative to a...
summary-PseudoSimulations-method
Summarize the simulations, relative to a given truth
summary-Simulations-method
Summarize the model-based design simulations, relative to a...
TDDesign
Initialization function for 'TDDesign' class
TDDesign-class
Design class using DLE responses only based on the pseudo DLE...
TDsamplesDesign
Initialization function for 'TDsamplesDesign' class
TDsamplesDesign-class
This is a class of design based only on DLE responses using...
ThreePlusThreeDesign
Creates a new 3+3 design object from a dose grid
update-DataDual-method
Update method for the "DataDual" class
update-Data-method
Update method for the "Data" class
update-DataParts-method
Update method for the "DataParts" class
update-EffFlexi-method
Update method for the 'EffFlexi' Model class. This is a...
update-Effloglog-method
Update method for the 'Effloglog' Model class. This is a...
update-LogisticIndepBeta-method
Update method for the 'LogisticIndepBeta'Model class. This is...
Validate
A Reference Class to help programming validation for new S4...
writeModel
Creating a WinBUGS model file

Files in this package

crmPack
crmPack/TODO
crmPack/inst
crmPack/inst/crmPack.pdf
crmPack/inst/NEWS
crmPack/inst/doc
crmPack/inst/doc/example.R
crmPack/inst/doc/example.Rnw
crmPack/inst/doc/example.pdf
crmPack/NAMESPACE
crmPack/R
crmPack/R/Model-class.R
crmPack/R/Rules-class.R
crmPack/R/Samples-class.R
crmPack/R/helpers.R
crmPack/R/McmcOptions-methods.R
crmPack/R/Data-methods.R
crmPack/R/Simulations-methods.R
crmPack/R/McmcOptions-class.R
crmPack/R/fromQuantiles.R
crmPack/R/writeModel.R
crmPack/R/Model-methods.R
crmPack/R/Simulations-class.R
crmPack/R/Samples-methods.R
crmPack/R/Design-methods.R
crmPack/R/crmPack-package.R
crmPack/R/Data-class.R
crmPack/R/Rules-methods.R
crmPack/R/mcmc.R
crmPack/R/Design-class.R
crmPack/vignettes
crmPack/vignettes/tikzlibrarypositioning-plus.code.tex
crmPack/vignettes/Sweave.pdf
crmPack/vignettes/example.bib
crmPack/vignettes/example.Rnw
crmPack/vignettes/mySweave.sty
crmPack/vignettes/auto
crmPack/vignettes/auto/example.el
crmPack/vignettes/package-concordance.tex
crmPack/MD5
crmPack/build
crmPack/build/vignette.rds
crmPack/DESCRIPTION
crmPack/ChangeLog
crmPack/man
crmPack/man/DualEndpointBeta-class.Rd
crmPack/man/plot-Samples-Model-method.Rd
crmPack/man/setSeed.Rd
crmPack/man/DualResponsesSamplesDesign.Rd
crmPack/man/show-PseudoDualSimulationsSummary-method.Rd
crmPack/man/GeneralSimulations-class.Rd
crmPack/man/NextBestMaxGain.Rd
crmPack/man/IncrementsRelativeParts-class.Rd
crmPack/man/StoppingMinPatients-class.Rd
crmPack/man/StoppingList-class.Rd
crmPack/man/StoppingAll-class.Rd
crmPack/man/NextBestTD-class.Rd
crmPack/man/fit.Rd
crmPack/man/CohortSizeMin-class.Rd
crmPack/man/RuleDesign-class.Rd
crmPack/man/LogisticIndepBeta.Rd
crmPack/man/update-DataParts-method.Rd
crmPack/man/IncrementsRelativeDLT.Rd
crmPack/man/LogisticNormalFixedMixture.Rd
crmPack/man/DualResponsesDesign-class.Rd
crmPack/man/crmPackExample.Rd
crmPack/man/NextBestDualEndpoint-class.Rd
crmPack/man/NextBestTD.Rd
crmPack/man/PseudoSimulationsSummary-class.Rd
crmPack/man/LogisticNormal-class.Rd
crmPack/man/LogisticLogNormalMixture.Rd
crmPack/man/Effloglog-class.Rd
crmPack/man/is.scalar.Rd
crmPack/man/StoppingTargetBiomarker-class.Rd
crmPack/man/StoppingTargetProb-class.Rd
crmPack/man/StoppingAll.Rd
crmPack/man/nextBest.Rd
crmPack/man/or-Stopping-StoppingAny.Rd
crmPack/man/NextBestDualEndpoint.Rd
crmPack/man/PseudoDualSimulationsSummary-class.Rd
crmPack/man/Design.Rd
crmPack/man/NextBestMaxGain-class.Rd
crmPack/man/PseudoDualSimulations-class.Rd
crmPack/man/DualEndpointRW-class.Rd
crmPack/man/stopTrial.Rd
crmPack/man/update-LogisticIndepBeta-method.Rd
crmPack/man/simulate-Design-method.Rd
crmPack/man/simulate-DualResponsesDesign-method.Rd
crmPack/man/summary-GeneralSimulations-method.Rd
crmPack/man/Quantiles2LogisticNormal.Rd
crmPack/man/Data-class.Rd
crmPack/man/Simulations.Rd
crmPack/man/CohortSizeMax-class.Rd
crmPack/man/ModelTox-class.Rd
crmPack/man/Samples.Rd
crmPack/man/IncrementsRelative.Rd
crmPack/man/plot-DataDual-ModelEff-method.Rd
crmPack/man/NextBestTDsamples-class.Rd
crmPack/man/DualSimulationsSummary-class.Rd
crmPack/man/plot.gtable.Rd
crmPack/man/NextBestThreePlusThree-class.Rd
crmPack/man/plotGain.Rd
crmPack/man/LogisticNormalMixture.Rd
crmPack/man/StoppingPatientsNearDose-class.Rd
crmPack/man/writeModel.Rd
crmPack/man/is.probability.Rd
crmPack/man/PseudoDualFlexiSimulations.Rd
crmPack/man/Design-class.Rd
crmPack/man/NextBestMaxGainSamples.Rd
crmPack/man/update-Data-method.Rd
crmPack/man/NextBestNCRM.Rd
crmPack/man/show-GeneralSimulationsSummary-method.Rd
crmPack/man/is.wholenumber.Rd
crmPack/man/LogisticLogNormalMixture-class.Rd
crmPack/man/Effloglog.Rd
crmPack/man/CohortSizeMax.Rd
crmPack/man/GeneralData-class.Rd
crmPack/man/StoppingPatientsNearDose.Rd
crmPack/man/LogisticNormalMixture-class.Rd
crmPack/man/TDsamplesDesign-class.Rd
crmPack/man/plot-DualSimulationsSummary-missing-method.Rd
crmPack/man/RuleDesign.Rd
crmPack/man/DualEndpointEmax.Rd
crmPack/man/StoppingHighestDose-class.Rd
crmPack/man/minSize.Rd
crmPack/man/PseudoDualSimulations.Rd
crmPack/man/summary-PseudoDualFlexiSimulations-method.Rd
crmPack/man/StoppingList.Rd
crmPack/man/ExpEff.Rd
crmPack/man/get-Samples-character-method.Rd
crmPack/man/prob.Rd
crmPack/man/NextBestNCRM-class.Rd
crmPack/man/or-Stopping-Stopping.Rd
crmPack/man/DataParts-class.Rd
crmPack/man/DataDual.Rd
crmPack/man/EffFlexi-class.Rd
crmPack/man/Model-class.Rd
crmPack/man/plot-DualSimulations-missing-method.Rd
crmPack/man/safeInteger.Rd
crmPack/man/DataParts.Rd
crmPack/man/initialize-DualEndpointOld-method.Rd
crmPack/man/Simulations-class.Rd
crmPack/man/StoppingAny-class.Rd
crmPack/man/EffFlexi.Rd
crmPack/man/DualSimulations-class.Rd
crmPack/man/ModelPseudo-class.Rd
crmPack/man/plot-PseudoDualSimulationsSummary-missing-method.Rd
crmPack/man/gain.Rd
crmPack/man/summary-DualSimulations-method.Rd
crmPack/man/dose.Rd
crmPack/man/show-SimulationsSummary-method.Rd
crmPack/man/joinBodies.Rd
crmPack/man/CohortSizeConst-class.Rd
crmPack/man/update-DataDual-method.Rd
crmPack/man/DualEndpoint.Rd
crmPack/man/and-Stopping-Stopping-method.Rd
crmPack/man/joinModels.Rd
crmPack/man/Validate.Rd
crmPack/man/plot-Samples-ModelEff-method.Rd
crmPack/man/examine.Rd
crmPack/man/summary-Simulations-method.Rd
crmPack/man/plotDualResponses.Rd
crmPack/man/AllModels-class.Rd
crmPack/man/LogisticLogNormalSub.Rd
crmPack/man/StoppingCohortsNearDose-class.Rd
crmPack/man/show-PseudoSimulationsSummary-method.Rd
crmPack/man/maxSize.Rd
crmPack/man/IncrementsRelative-class.Rd
crmPack/man/approximate.Rd
crmPack/man/ThreePlusThreeDesign.Rd
crmPack/man/biomLevel.Rd
crmPack/man/or-StoppingAny-Stopping.Rd
crmPack/man/DualDesign.Rd
crmPack/man/CohortSizeParts-class.Rd
crmPack/man/LogisticKadane-class.Rd
crmPack/man/logit.Rd
crmPack/man/CohortSize-class.Rd
crmPack/man/qinvGamma.Rd
crmPack/man/IncrementsRelativeParts.Rd
crmPack/man/GeneralSimulationsSummary-class.Rd
crmPack/man/StoppingGstarCIRatio-class.Rd
crmPack/man/DualResponsesSamplesDesign-class.Rd
crmPack/man/and-Stopping-StoppingAll-method.Rd
crmPack/man/CohortSizeConst.Rd
crmPack/man/LogisticKadane.Rd
crmPack/man/DualDesign-class.Rd
crmPack/man/CohortSizeDLT-class.Rd
crmPack/man/DualSimulations.Rd
crmPack/man/simulate-TDDesign-method.Rd
crmPack/man/PseudoSimulations-class.Rd
crmPack/man/DataMixture-class.Rd
crmPack/man/getMinInfBeta.Rd
crmPack/man/DualEndpointOld-class.Rd
crmPack/man/dinvGamma.Rd
crmPack/man/NextBestMTD-class.Rd
crmPack/man/StoppingMTDdistribution-class.Rd
crmPack/man/plot-Samples-ModelTox-method.Rd
crmPack/man/StoppingMinCohorts-class.Rd
crmPack/man/StoppingHighestDose.Rd
crmPack/man/TDDesign-class.Rd
crmPack/man/DataDual-class.Rd
crmPack/man/LogisticLogNormalSub-class.Rd
crmPack/man/CohortSizeDLT.Rd
crmPack/man/Data.Rd
crmPack/man/myBarplot.Rd
crmPack/man/Increments-class.Rd
crmPack/man/StoppingTargetProb.Rd
crmPack/man/simulate-RuleDesign-method.Rd
crmPack/man/size.Rd
crmPack/man/CohortSizeRange-class.Rd
crmPack/man/maxDose.Rd
crmPack/man/plot-Data-ModelTox-method.Rd
crmPack/man/multiplot.Rd
crmPack/man/StoppingMinCohorts.Rd
crmPack/man/NextBestMaxGainSamples-class.Rd
crmPack/man/plot-PseudoDualFlexiSimulations-missing-method.Rd
crmPack/man/update-EffFlexi-method.Rd
crmPack/man/StoppingTargetBiomarker.Rd
crmPack/man/noOverlap.Rd
crmPack/man/getEff.Rd
crmPack/man/LogisticIndepBeta-class.Rd
crmPack/man/StoppingMTDdistribution.Rd
crmPack/man/plot-Data-missing-method.Rd
crmPack/man/ModelEff-class.Rd
crmPack/man/NextBestMTD.Rd
crmPack/man/printVignette.Rd
crmPack/man/plot-GeneralSimulations-missing-method.Rd
crmPack/man/update-Effloglog-method.Rd
crmPack/man/Samples-class.Rd
crmPack/man/StoppingTDCIRatio-class.Rd
crmPack/man/plot-PseudoDualSimulations-missing-method.Rd
crmPack/man/DualEndpointBeta.Rd
crmPack/man/PseudoDualFlexiSimulations-class.Rd
crmPack/man/and-StoppingAll-Stopping-method.Rd
crmPack/man/summary-PseudoSimulations-method.Rd
crmPack/man/StoppingTDCIRatio.Rd
crmPack/man/DualEndpoint-class.Rd
crmPack/man/DualEndpointEmax-class.Rd
crmPack/man/DataMixture.Rd
crmPack/man/MinimalInformative.Rd
crmPack/man/TDDesign.Rd
crmPack/man/PseudoSimulations.Rd
crmPack/man/crmPack-package.Rd
crmPack/man/DualEndpointRW.Rd
crmPack/man/IncrementsRelativeDLT-class.Rd
crmPack/man/StoppingCohortsNearDose.Rd
crmPack/man/McmcOptions-class.Rd
crmPack/man/CohortSizeRange.Rd
crmPack/man/is.probRange.Rd
crmPack/man/sampleSize.Rd
crmPack/man/LogisticLogNormal-class.Rd
crmPack/man/plot-SimulationsSummary-missing-method.Rd
crmPack/man/rinvGamma.Rd
crmPack/man/LogisticNormal.Rd
crmPack/man/crmPackHelp.Rd
crmPack/man/CohortSizeParts.Rd
crmPack/man/plot-PseudoSimulationsSummary-missing-method.Rd
crmPack/man/simulate-DualResponsesSamplesDesign-method.Rd
crmPack/man/as.list-GeneralData-method.Rd
crmPack/man/GeneralSimulations.Rd
crmPack/man/GeneralModel-class.Rd
crmPack/man/summary-PseudoDualSimulations-method.Rd
crmPack/man/Stopping-class.Rd
crmPack/man/is.bool.Rd
crmPack/man/Report.Rd
crmPack/man/NextBestTDsamples.Rd
crmPack/man/StoppingMinPatients.Rd
crmPack/man/saveSample.Rd
crmPack/man/LogisticNormalFixedMixture-class.Rd
crmPack/man/plot-DataDual-missing-method.Rd
crmPack/man/fitGain.Rd
crmPack/man/DualResponsesDesign.Rd
crmPack/man/simulate-TDsamplesDesign-method.Rd
crmPack/man/show-DualSimulationsSummary-method.Rd
crmPack/man/NextBest-class.Rd
crmPack/man/StoppingGstarCIRatio.Rd
crmPack/man/CohortSizeMin.Rd
crmPack/man/simulate-DualDesign-method.Rd
crmPack/man/pinvGamma.Rd
crmPack/man/McmcOptions.Rd
crmPack/man/NextBestThreePlusThree.Rd
crmPack/man/LogisticLogNormal.Rd
crmPack/man/getResultList.Rd
crmPack/man/SimulationsSummary-class.Rd
crmPack/man/plot-GeneralSimulationsSummary-missing-method.Rd
crmPack/man/TDsamplesDesign.Rd
crmPack/man/StoppingAny.Rd
crmPack/man/mcmc.Rd
crmPack/man/plot-Samples-DualEndpoint-method.Rd