DualEndpointEmax-class: Dual endpoint model with emax function for dose-biomarker... In crmPack: Object-Oriented Implementation of CRM Designs

Description

This class extends the DualEndpoint class. Here the dose-biomarker relationship f(x) is modelled by a parametric EMAX function:

Details

f(x) = E_{0} + \frac{(E_{max} - E_{0}) * (x/x^{*})}{ED_{50} + (x/x^{*})}

where x^{*} is a reference dose, E_{0} and E_{max} are the minimum and maximum levels for the biomarker and ED_{50} is the dose achieving half of the maximum effect 0.5 * E_{max}.

All parameters can currently be assigned uniform distributions or be fixed in advance.

Slots

E0

either a fixed number or the two uniform distribution parameters

Emax

either a fixed number or the two uniform distribution parameters

ED50

either a fixed number or the two uniform distribution parameters

refDoseEmax

the reference dose x^{*}

Examples

 1 2 3 4 5 6 7 8 model <- DualEndpointEmax(E0 = c(0, 100), Emax = c(0, 500), ED50 = c(10,200), refDoseEmax = 1000, mu = c(0, 1), Sigma = matrix(c(1, 0, 0, 1), nrow=2), sigma2W = c(a=0.1, b=0.1), rho = c(a=1, b=1)) 

crmPack documentation built on June 13, 2019, 9:02 a.m.