Description Details Slots Examples

This class extends the `DualEndpoint`

class. Here the
dose-biomarker relationship *f(x)* is modelled by a parametric EMAX function:

*f(x) = E_{0} + \frac{(E_{max} - E_{0}) * (x/x^{*})}{ED_{50} + (x/x^{*})}*

where *x^{*}* is a reference dose, *E_{0}* and *E_{max}* are the
minimum and maximum levels for the biomarker and *ED_{50}* is the dose
achieving half of the maximum effect *0.5 * E_{max}*.

All parameters can currently be assigned uniform distributions or be fixed in advance.

`E0`

either a fixed number or the two uniform distribution parameters

`Emax`

either a fixed number or the two uniform distribution parameters

`ED50`

either a fixed number or the two uniform distribution parameters

`refDoseEmax`

the reference dose

*x^{*}*

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