dfpk: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials

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Includes methods involving PK measures in the dose allocation process during a Phase I clinical trials. These methods enter PK in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate scenarios, and to run simulations which their objective is to determine the maximum tolerated dose (MTD) and to investigate PK of a drug or a combination of drugs.

Author
Artemis Toumazi <artemis.toumazi@inserm.fr> , Moreno Ursino <moreno.ursino@inserm.fr> and Sarah Zohar <sarah.zohar@inserm.fr>
Date of publication
2016-08-10 10:06:56
Maintainer
Artemis Toumazi <artemis.toumazi@inserm.fr>
License
GPL (>= 3)
Version
1.0
URLs

View on CRAN

Man pages

AUC_estim
Estimation of the area under the curve, AUC.
dfpk-package
A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for...
dosefinding-class
An S4 class to represent a dosefinding results.
dtox
Dose finding method DTOX
invlogit
Inverse logistic functions
nsim
More than one simulation using PK measure in the dose finding...
pkcov
Dose finding method PKCOV
pkcrm
Dose finding method PKCRM
pk.estim
PK measure of exposure
pklogit
Dose finding method PKLOGIT
pkpop
Dose finding method PKPOP
pktox
Dose finding method PKTOX
plotConc
The generic function of plot.conc
plotConc-scen-method
The graphical representation of the drug's concentration in...
plotDose
The generic function of the plot.dose
plotDose-dosefinding-method
The graphical representation of dose escalation for each...
scenarios
Generate New Scenarios
scen-class
An S4 class to represent a simulated scenarios.
show-methods
S4 Methods for Function 'show'
sim
One simulation using PK measure in the dose finding design.
stan_f
The data stan_f includes all the Stan models that dfpk...

Files in this package

dfpk
dfpk/inst
dfpk/inst/chunks
dfpk/inst/chunks/license.stan
dfpk/inst/chunks/common_functions.txt
dfpk/exec
dfpk/exec/logit_cov2.stan
dfpk/exec/logit_reg.stan
dfpk/exec/logit_reg_dtox.stan
dfpk/exec/reg_auc2.stan
dfpk/exec/logit_reg_pkpop.stan
dfpk/src
dfpk/src/Makevars
dfpk/src/Modules.cpp
dfpk/src/include
dfpk/src/include/models.hpp
dfpk/NAMESPACE
dfpk/data
dfpk/data/stan_f.rda
dfpk/R
dfpk/R/pklogit.R
dfpk/R/pk.estim.R
dfpk/R/AUC_estim.R
dfpk/R/stanmodels.R
dfpk/R/pkcrm.R
dfpk/R/invlogit.R
dfpk/R/pkpop.R
dfpk/R/nsim.R
dfpk/R/pktox.R
dfpk/R/scenarios.R
dfpk/R/dtox.R
dfpk/R/sim.R
dfpk/R/S4_classes.R
dfpk/R/dfpk-internal.R
dfpk/R/zzz.R
dfpk/R/pkcov.R
dfpk/README.md
dfpk/MD5
dfpk/DESCRIPTION
dfpk/man
dfpk/man/dfpk-package.Rd
dfpk/man/plotDose-dosefinding-method.Rd
dfpk/man/scenarios.Rd
dfpk/man/plotDose.Rd
dfpk/man/invlogit.Rd
dfpk/man/dosefinding-class.Rd
dfpk/man/AUC_estim.Rd
dfpk/man/pkcrm.Rd
dfpk/man/dtox.Rd
dfpk/man/pkpop.Rd
dfpk/man/pkcov.Rd
dfpk/man/pk.estim.Rd
dfpk/man/pktox.Rd
dfpk/man/stan_f.Rd
dfpk/man/plotConc.Rd
dfpk/man/pklogit.Rd
dfpk/man/nsim.Rd
dfpk/man/plotConc-scen-method.Rd
dfpk/man/scen-class.Rd
dfpk/man/sim.Rd
dfpk/man/show-methods.Rd
dfpk/tools
dfpk/tools/make_cpp.R