Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).
|Author||Artemis Toumazi <[email protected]>, Moreno Ursino <[email protected]> and Sarah Zohar <[email protected]>|
|Date of publication||2017-06-30 13:28:18 UTC|
|Maintainer||Artemis Toumazi <[email protected]>|
|License||GPL (>= 3) | file LICENSE|
|Package repository||View on CRAN|
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