dfpk: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials

Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objectives are to determine the maximum tolerated dose (MTD) and to investigate the pharmacokinetics of a drug or a combination of drugs.

Install the latest version of this package by entering the following in R:
install.packages("dfpk")
AuthorArtemis Toumazi <artemis.toumazi@inserm.fr> , Moreno Ursino <moreno.ursino@inserm.fr> and Sarah Zohar <sarah.zohar@inserm.fr>
Date of publication2017-03-11 18:50:39
MaintainerArtemis Toumazi <artemis.toumazi@inserm.fr>
LicenseGPL (>= 3) | file LICENSE
Version2.1.0
http://github.com/artemis-toumazi/dfpk

View on CRAN

Functions

AUC_estim Man page
dfpk Man page
dfpk-package Man page
Dose-class Man page
dosefinding-class Man page
dtox Man page
invlogit Man page
nextDose Man page
nsim Man page
pkcov Man page
pkcrm Man page
pk.estim Man page
pklogit Man page
pkpop Man page
pktox Man page
plotConc Man page
plotConc,scen-method Man page
plotDose Man page
plotDose,dosefinding-method Man page
scenarios Man page
scen-class Man page
show,dosefinding-method Man page
show,Dose-method Man page
show-methods Man page
show,scen-method Man page
stan_f Man page

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

Please suggest features or report bugs with the GitHub issue tracker.

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