Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objectives are to determine the maximum tolerated dose (MTD) and to investigate the pharmacokinetics of a drug or a combination of drugs.
|Author||Artemis Toumazi <firstname.lastname@example.org> , Moreno Ursino <email@example.com> and Sarah Zohar <firstname.lastname@example.org>|
|Date of publication||2016-12-15 11:03:17|
|Maintainer||Artemis Toumazi <email@example.com>|
|License||GPL (>= 3)|
AUC_estim: Estimation of the area under the curve, AUC.
dfpk-package: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for...
Dose-class: An S4 class to present the next recommended dose level in an...
dosefinding-class: An S4 class to represent a dosefinding results.
dtox: Dose finding method DTOX.
invlogit: Inverse logistic functions.
nextDose: Next dose determination of a phase I clinical trial.
nsim: Simulate one or more Phase I clinical trial(s) using the PK...
pkcov: Dose finding method PKCOV.
pkcrm: Dose finding method PKCRM.
pk.estim: The pharmacokinetic's (PK) measure of exposure.
pklogit: Dose finding method PKLOGIT.
pkpop: Dose finding method PKPOP.
pktox: Dose finding method PKTOX.
plotConc: The generic function of plot.conc.
plotConc-scen-method: The graphical representation of the drug's concentration in...
plotDose: The generic function of the plot.dose.
plotDose-dosefinding-method: The graphical representation of dose escalation for each...
scenarios: Generate new data from a scenarios.
scen-class: An S4 class to represent a simulated scenarios.
show-methods: S4 Methods for Function 'show'
stan_f: The data stan_f includes all the Stan models that dfpk...