dfpk: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials
Version 3.0.1

Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).

Browse man pages Browse package API and functions Browse package files

AuthorArtemis Toumazi <artemis.toumazi@inserm.fr> , Moreno Ursino <moreno.ursino@inserm.fr> and Sarah Zohar <sarah.zohar@inserm.fr>
Date of publication2017-05-14 19:38:33 UTC
MaintainerArtemis Toumazi <artemis.toumazi@inserm.fr>
LicenseGPL (>= 3) | file LICENSE
Version3.0.1
URL http://github.com/artemis-toumazi/dfpk
Package repositoryView on CRAN
InstallationInstall the latest version of this package by entering the following in R:
install.packages("dfpk")

Man pages

AUC.estim: Estimation of the area under the curve, AUC.
dfpk-package: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for...
Dose-class: An S4 class to present the next recommended dose level in an...
dosefinding-class: An S4 class to represent a dosefinding results.
dtox: Dose finding method DTOX.
invlogit: Inverse logistic functions.
nextDose: Next dose determination of a phase I clinical trial.
nsim: Simulate one or more Phase I clinical trial(s) using the PK...
pkcov: Dose finding method PKCOV.
pkcrm: Dose finding method PKCRM.
pk.estim: The pharmacokinetic's (PK) measure of exposure.
pklogit: Dose finding method PKLOGIT.
pkpop: Dose finding method PKPOP.
pktox: Dose finding method PKTOX.
plot-dosefinding-missing-method: The graphical representation of dose escalation for each...
plot-Dose-missing-method: The graphical representation of dose escalation for each...
plot-scen-missing-method: The graphical representation of the drug's concentration in...
scen-class: An S4 class to represent a simulated scenarios.
show-methods: S4 Methods for Function 'show'
sim.data: Generate new PK and toxicity data.
stan_f: The data stan_f includes all the Stan models that dfpk...

Functions

AUC.estim Man page Source code
Dose-class Man page
dfpk Man page
dfpk-package Man page
dosefinding-class Man page
dtox Man page Source code
invlogit Man page Source code
nextDose Man page Source code
nsim Man page Source code
onLoad Source code
pk.estim Man page Source code
pkcov Man page Source code
pkcrm Man page Source code
pklogit Man page Source code
pkpop Man page Source code
pktox Man page Source code
plot,Dose,missing-method Man page
plot,dosefinding,missing-method Man page
plot,scen,missing-method Man page
scen-class Man page
show,Dose-method Man page
show,dosefinding-method Man page
show,scen-method Man page
show-methods Man page
sim.data Man page Source code
stan_f Man page

Files

inst
inst/chunks
inst/chunks/license.stan
inst/chunks/common_functions.txt
exec
exec/logit_cov2.stan
exec/logit_reg.stan
exec/logit_reg_dtox.stan
exec/reg_auc2.stan
exec/logit_reg_pkpop.stan
src
src/Makevars
src/init.c
src/Modules.cpp
src/include
src/include/models.hpp
NAMESPACE
data
data/stan_f.rda
R
R/pklogit.R
R/pk.estim.R
R/sim.data.R
R/nextDose.R
R/stanmodels.R
R/pkcrm.R
R/invlogit.R
R/pkpop.R
R/nsim.R
R/pktox.R
R/dtox.R
R/S4_classes.R
R/AUC.estim.R
R/dfpk-internal.R
R/zzz.R
R/pkcov.R
README.md
MD5
DESCRIPTION
man
man/dfpk-package.Rd
man/AUC.estim.Rd
man/Dose-class.Rd
man/plot-dosefinding-missing-method.Rd
man/invlogit.Rd
man/dosefinding-class.Rd
man/nextDose.Rd
man/pkcrm.Rd
man/dtox.Rd
man/sim.data.Rd
man/pkpop.Rd
man/pkcov.Rd
man/pk.estim.Rd
man/pktox.Rd
man/plot-scen-missing-method.Rd
man/stan_f.Rd
man/pklogit.Rd
man/nsim.Rd
man/scen-class.Rd
man/plot-Dose-missing-method.Rd
man/show-methods.Rd
tools
tools/make_cpp.R
LICENSE
dfpk documentation built on May 19, 2017, 3:43 p.m.