dose-class: An S4 class to perform parameter estimation at each step...

In dfpk: Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials

Description

An S4 class to perform parameter estimation at each step during a dose-finding trial.

Slots

N

The total number of enrolled patients.

y

A binary vector of toxicity outcomes from previous patients; 1 indicates a toxicity, 0 otherwise.

AUCs

A vector with the computed AUC values of each patient.

doses

A vector with the doses panel.

x

A vector with the dose level assigned to the patients.

theta

The toxicity threshold.

options

a list of Stan model's options.

newDose

The next recommended dose (RD) level; equals to 0 if the trial has stopped, according to the stopping rules.

pstim

The estimated mean probabilities of toxicity.

pstimQ1

The 1st quartile of estimated probability of toxicity.

pstimQ3

The 3rd quartile of estimated probability of toxicity.

parameters

The Stan model's estimated parameters.

model

A character string to specify the selected dose-finding model. See for details dtox, pkcov, pkcrm, pktox, pkpop, pklogit.

dfpk documentation built on May 2, 2019, 8:31 a.m.