HubStatus: Hub status of the genes in a gene co-expression network

Description Usage Arguments Value Author(s) Examples

View source: R/dhga.R

Description

The function returns hub status of each gene in a gene co-expression network (GCN)

Usage

1
HubStatus(pvalue.stress, pvalue.control, alpha)

Arguments

pvalue.stress

pvalue.stress is a vector of p-values for genes in the GCN under stress condition. pvalue.stress can be obtained from the output of hub.stress function.

pvalue.control

pvalue.control is a vector of p-values for genes in the GCN under normal or control condition. pvalue.control can be obtained from the output of hub.control function.

alpha

alpha is a scalar representing statistical level of significance. Default is alpha=0.0001

Value

The function returns a list with two components. First component returns the list of genes along with their hub status. Second component gives a table containing number of genes under different categories of hubs viz. housekeeping, unique to stress and unique to normal

Author(s)

Samarendra Das and Baidya Nath Mandal

Examples

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data(rice_salt)
pval.stres <- pvalue.hub(rice_salt, beta=6, m=18, s=80, plot=FALSE)
p1 <- pval.stres[, 2]

data(rice_normal)
pval.control <- pvalue.hub(rice_normal, beta=6, m=18, s=80, plot=FALSE)
p2 <- pval.control[, 2]
HubStatus(p1,p2,alpha=0.0001)

Example output

Loading required package: VennDiagram
Loading required package: grid
Loading required package: futile.logger
$hub.status
                      Genes           Hub Status
1           Os.9805.1.S1_at              Not Hub
2           Os.8149.1.S1_at              Not Hub
3          Os.51343.1.S1_at     Housekeeping Hub
4           Os.2881.1.S1_at              Not Hub
5          Os.55524.1.S1_at     Housekeeping Hub
6        Os.22029.1.S1_a_at     Housekeeping Hub
7       OsAffx.3191.1.A1_at              Not Hub
8      OsAffx.12383.1.S1_at     Housekeeping Hub
9        Os.52157.1.S1_x_at Unique Hub to Stress
10       Os.26770.2.S1_x_at     Housekeeping Hub
11          Os.5140.1.S1_at              Not Hub
12          Os.2128.1.S1_at Unique Hub to Normal
13         Os.25613.1.A1_at     Housekeeping Hub
14         Os.32686.1.S1_at              Not Hub
15     OsAffx.27459.3.S1_at     Housekeeping Hub
16         Os.10487.1.S1_at              Not Hub
17         Os.31191.1.S1_at     Housekeeping Hub
18         Os.53177.1.S1_at              Not Hub
19         Os.40338.1.S1_at Unique Hub to Normal
20         Os.31171.1.S1_at Unique Hub to Normal
21     OsAffx.25039.1.S1_at     Housekeeping Hub
22     OsAffx.12783.1.S1_at     Housekeeping Hub
23         Os.47413.1.S1_at     Housekeeping Hub
24       Os.38638.4.S1_s_at Unique Hub to Stress
25        Os.4819.1.A1_s_at     Housekeeping Hub
26         Os.33971.1.S1_at Unique Hub to Stress
27         Os.18955.1.S1_at Unique Hub to Stress
28         Os.30269.1.S1_at              Not Hub
29         Os.38812.1.S1_at              Not Hub
30         Os.49650.1.S1_at              Not Hub
31   OsAffx.27459.3.S1_x_at     Housekeeping Hub
32     OsAffx.28409.1.S1_at     Housekeeping Hub
33       Os.11151.1.S1_a_at              Not Hub
34         Os.26511.1.S1_at              Not Hub
35         Os.41199.1.A1_at              Not Hub
36       Os.40007.1.S1_x_at Unique Hub to Stress
37         Os.10389.1.S1_at     Housekeeping Hub
38     OsAffx.20682.1.S1_at Unique Hub to Stress
39         Os.11272.1.S1_at     Housekeeping Hub
40          Os.9445.1.S1_at              Not Hub
41         Os.48215.1.A1_at Unique Hub to Stress
42          Os.8673.1.S1_at              Not Hub
43          Os.1465.1.S1_at              Not Hub
44       Os.53177.1.S1_s_at              Not Hub
45   OsAffx.28409.2.S1_s_at     Housekeeping Hub
46         Os.53439.1.S1_at Unique Hub to Normal
47         Os.12629.1.S1_at     Housekeeping Hub
48         Os.11555.1.S1_at     Housekeeping Hub
49         Os.11898.1.S1_at              Not Hub
50         Os.56232.1.S1_at Unique Hub to Normal
51     OsAffx.20930.1.S1_at              Not Hub
52         Os.47737.1.S1_at Unique Hub to Stress
53     OsAffx.17611.1.S1_at Unique Hub to Stress
54       Os.38638.3.S1_x_at     Housekeeping Hub
55         Os.52100.1.S1_at              Not Hub
56          Os.7770.1.S1_at              Not Hub
57          Os.9836.1.S1_at              Not Hub
58         Os.16744.1.S1_at              Not Hub
59         Os.51307.1.S1_at     Housekeeping Hub
60     OsAffx.26317.1.S2_at Unique Hub to Stress
61      OsAffx.2166.1.S1_at Unique Hub to Normal
62          Os.5621.1.S1_at              Not Hub
63         Os.11787.1.S1_at              Not Hub
64         Os.33625.4.S1_at              Not Hub
65     OsAffx.31756.4.S1_at     Housekeeping Hub
66         Os.50805.1.S1_at Unique Hub to Normal
67     OsAffx.29448.1.S1_at     Housekeeping Hub
68         Os.11801.1.S1_at Unique Hub to Stress
69         Os.47802.1.A1_at              Not Hub
70     OsAffx.18861.1.S1_at Unique Hub to Normal
71         Os.56150.1.S1_at              Not Hub
72         Os.12642.1.S1_at              Not Hub
73         Os.10469.1.S1_at Unique Hub to Normal
74         Os.55079.1.S1_at Unique Hub to Normal
75         Os.34174.1.S1_at              Not Hub
76     OsAffx.12433.1.S1_at     Housekeeping Hub
77         Os.50369.1.S1_at              Not Hub
78     OsAffx.15447.1.S1_at              Not Hub
79         Os.52619.1.S1_at              Not Hub
80         Os.17102.1.S1_at     Housekeeping Hub
81     OsAffx.30295.1.S1_at     Housekeeping Hub
82       Os.11800.1.S1_s_at              Not Hub
83       Os.10654.1.S1_s_at     Housekeeping Hub
84       Os.54579.1.S1_s_at     Housekeeping Hub
85      OsAffx.3569.1.S1_at Unique Hub to Normal
86         Os.55907.1.S1_at     Housekeeping Hub
87         Os.52058.1.S1_at              Not Hub
88       Os.57456.1.S1_x_at Unique Hub to Stress
89         Os.155.1.S1_a_at Unique Hub to Normal
90          Os.6345.1.S1_at              Not Hub
91       Os.11677.1.S1_x_at     Housekeeping Hub
92      OsAffx.8061.1.S1_at              Not Hub
93     OsAffx.13662.1.S1_at              Not Hub
94         Os.15199.1.S1_at              Not Hub
95       Os.31778.2.S1_x_at     Housekeeping Hub
96         Os.39994.1.S1_at              Not Hub
97         Os.50372.1.S1_at              Not Hub
98         Os.18381.1.S1_at              Not Hub
99         Os.11796.1.S1_at              Not Hub
100    OsAffx.19632.1.S1_at     Housekeeping Hub
101      Os.12767.1.S1_a_at Unique Hub to Normal
102      Os.34061.1.S1_a_at              Not Hub
103        Os.12239.1.S1_at              Not Hub
104      Os.49780.1.S1_x_at Unique Hub to Stress
105     OsAffx.7332.1.S1_at     Housekeeping Hub
106      Os.36162.1.S1_s_at Unique Hub to Normal
107        Os.44475.1.S1_at              Not Hub
108        Os.54555.1.S1_at     Housekeeping Hub
109      Os.15247.1.S1_s_at              Not Hub
110         Os.6683.1.S1_at Unique Hub to Normal
111        Os.56924.1.S1_at     Housekeeping Hub
112    OsAffx.15530.1.S1_at     Housekeeping Hub
113        Os.50290.1.S1_at     Housekeeping Hub
114        Os.57362.1.S1_at              Not Hub
115        Os.50883.1.S1_at     Housekeeping Hub
116        Os.12286.1.S1_at              Not Hub
117        Os.52536.1.S1_at              Not Hub
118         Os.6792.1.S1_at     Housekeeping Hub
119          Os.319.1.A1_at              Not Hub
120        Os.18933.1.S1_at              Not Hub
121         Os.4760.1.S1_at Unique Hub to Normal
122    OsAffx.30721.5.S1_at              Not Hub
123    OsAffx.15125.1.S1_at              Not Hub
124        Os.26802.1.S1_at              Not Hub
125        Os.11786.2.S1_at Unique Hub to Normal
126      Os.47413.1.S1_x_at     Housekeeping Hub
127        Os.24906.1.S1_at              Not Hub
128         Os.4715.1.S1_at              Not Hub
129        Os.534.2.S1_x_at     Housekeeping Hub
130         Os.8118.1.S1_at     Housekeeping Hub
131        Os.21319.1.S1_at Unique Hub to Normal
132        Os.23183.1.S1_at Unique Hub to Stress
133      Os.27659.1.S1_x_at              Not Hub
134        Os.23381.1.A1_at              Not Hub
135        Os.27759.1.S1_at              Not Hub
136     OsAffx.7934.1.S1_at     Housekeeping Hub
137        Os.54672.1.S1_at     Housekeeping Hub
138        Os.15471.1.S1_at Unique Hub to Normal
139        Os.31778.2.S1_at     Housekeeping Hub
140      Os.17652.1.S1_s_at Unique Hub to Normal
141    OsAffx.11963.1.S1_at Unique Hub to Normal
142    OsAffx.27299.1.S1_at              Not Hub
143       Os.5197.2.S1_x_at     Housekeeping Hub
144        Os.54653.1.S1_at     Housekeeping Hub
145        Os.16558.1.S1_at Unique Hub to Normal
146      Os.35154.1.S1_x_at     Housekeeping Hub
147        Os.54178.1.S1_at     Housekeeping Hub
148        Os.46710.2.S1_at              Not Hub
149        Os.54318.1.S1_at     Housekeeping Hub
150    OsAffx.13338.1.S1_at     Housekeeping Hub
151        Os.46869.1.A1_at Unique Hub to Normal
152      Os.44475.1.S1_x_at Unique Hub to Normal
153        Os.17997.1.S1_at Unique Hub to Normal
154        Os.32964.1.S1_at              Not Hub
155        Os.49294.1.S1_at Unique Hub to Stress
156        Os.26171.1.S1_at              Not Hub
157        Os.50450.1.S1_at              Not Hub
158    OsAffx.19332.1.S1_at Unique Hub to Stress
159    OsAffx.28727.1.S1_at     Housekeeping Hub
160        Os.16904.1.S1_at              Not Hub
161         Os.6825.1.S1_at              Not Hub
162     OsAffx.3504.1.S1_at              Not Hub
163         Os.4415.1.S1_at     Housekeeping Hub
164        Os.11834.1.S1_at              Not Hub
165        Os.37255.1.A1_at              Not Hub
166         Os.7674.1.S1_at              Not Hub
167      Os.56048.1.S1_s_at     Housekeeping Hub
168    OsAffx.15785.1.S1_at              Not Hub
169        Os.27624.1.S1_at Unique Hub to Stress
170    OsAffx.29866.1.S1_at Unique Hub to Stress
171   OsAffx.3569.1.S1_x_at Unique Hub to Normal
172         Os.6318.1.S1_at              Not Hub
173    OsAffx.27557.1.S1_at     Housekeeping Hub
174         Os.1479.1.S1_at Unique Hub to Normal
175    OsAffx.24515.1.S1_at     Housekeeping Hub
176        Os.51295.1.S1_at              Not Hub
177        Os.11255.1.S1_at     Housekeeping Hub
178  OsAffx.31756.4.S1_x_at     Housekeeping Hub
179        Os.49226.1.S1_at Unique Hub to Normal
180    OsAffx.17724.1.S1_at              Not Hub
181     OsAffx.3755.1.S1_at              Not Hub
182      Os.18664.1.S1_a_at              Not Hub
183        Os.33087.1.S1_at Unique Hub to Stress
184        Os.54146.1.S1_at     Housekeeping Hub
185      Os.11312.1.S1_s_at Unique Hub to Stress
186     OsAffx.4923.1.S1_at              Not Hub
187    OsAffx.29954.1.S1_at     Housekeeping Hub
188 OsAffx.27508.10.S1_s_at              Not Hub
189           Os.64.1.S1_at Unique Hub to Stress
190    OsAffx.30868.1.S1_at     Housekeeping Hub
191        Os.12986.1.S1_at Unique Hub to Normal
192        Os.52151.1.S1_at Unique Hub to Normal
193    OsAffx.31107.1.S1_at              Not Hub
194        Os.51491.1.S1_at              Not Hub
195        Os.11144.1.S1_at Unique Hub to Stress
196        Os.11308.1.S1_at Unique Hub to Stress
197        Os.40000.1.S1_at     Housekeeping Hub
198        Os.11251.1.S1_at     Housekeeping Hub
199         Os.5510.1.S1_at              Not Hub
200        Os.18830.1.S1_at              Not Hub

$out1

    Housekeeping Hub              Not Hub Unique Hub to Normal 
                  63                   84                   30 
Unique Hub to Stress 
                  23 

attr(,"class")
[1] "HubStatus_Genes"  "HubStatus_Matrix"

dhga documentation built on May 2, 2019, 2:13 p.m.

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