pvalue.hub: Compuation of gene connection sigificance values in a Gene...

Description Usage Arguments Value Author(s) Examples

Description

The function computes ths statisical significance values of gene connections in a GCN for a particular condition/trait/stress

Usage

1
pvalue.hub(x, beta, m, s, plot=TRUE)

Arguments

x

x is a data frame of gene expression values where rows represent genes and columns represent samples/time point under a particular condition/trait/stress.

beta

beta is a soft threshold parameter determined from the scale free property of biological networks (Gene Co-expression network).

m

m is a scalar representing sample size and is less than or equal to number of columns in x.

s

s is a scalar representing number of times each of the m samples will be resampled.

plot

plot is a character must either take logical value TRUE/FALSE representing whether the plot of the pvalues of gene connections of all genes in Gene Co-expression Network needs to be constructed or not.

Value

The function returns a vector of p-values for all the genes in the GCN

Author(s)

Samarendra Das and Baidya Nath Mandal

Examples

1
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6

Example output

Loading required package: VennDiagram
Loading required package: grid
Loading required package: futile.logger
                        Total degree      P value
Os.9805.1.S1_at            4.5810690 9.817441e-01
Os.8149.1.S1_at            7.1032280 5.895699e-02
Os.51343.1.S1_at          16.9268927 4.741483e-15
Os.2881.1.S1_at            3.5704524 1.000000e+00
Os.55524.1.S1_at          20.7553455 4.076179e-15
Os.22029.1.S1_a_at        27.4313197 3.924763e-15
OsAffx.3191.1.A1_at        0.4142027 1.000000e+00
OsAffx.12383.1.S1_at      27.5799813 3.924763e-15
Os.52157.1.S1_x_at        13.1212627 7.024013e-14
Os.26770.2.S1_x_at        19.7211313 3.924763e-15
Os.5140.1.S1_at            2.3975347 9.999999e-01
Os.2128.1.S1_at            6.0280124 2.378544e-05
Os.25613.1.A1_at          25.1919786 3.924763e-15
Os.32686.1.S1_at           6.6561918 1.582764e-02
OsAffx.27459.3.S1_at      20.1188165 3.924763e-15
Os.10487.1.S1_at           2.6201087 1.000000e+00
Os.31191.1.S1_at          18.9451339 3.924763e-15
Os.53177.1.S1_at           1.4485487 1.000000e+00
Os.40338.1.S1_at           2.6577520 1.000000e+00
Os.31171.1.S1_at           2.8151058 9.999998e-01
OsAffx.25039.1.S1_at      13.9001704 4.396463e-15
OsAffx.12783.1.S1_at      25.6927147 3.924763e-15
Os.47413.1.S1_at          16.6874146 3.924763e-15
Os.38638.4.S1_s_at         8.5650461 5.108386e-07
Os.4819.1.A1_s_at          8.7755289 1.494431e-06
Os.33971.1.S1_at          12.0471354 3.396754e-14
Os.18955.1.S1_at          14.2892244 1.511644e-14
Os.30269.1.S1_at           0.4164191 1.000000e+00
Os.38812.1.S1_at           6.4930384 3.157457e-01
Os.49650.1.S1_at           0.7103038 1.000000e+00
OsAffx.27459.3.S1_x_at    19.0337520 3.924763e-15
OsAffx.28409.1.S1_at       9.1243208 8.650034e-05
Os.11151.1.S1_a_at         4.2293946 9.906179e-01
Os.26511.1.S1_at           2.4860046 1.000000e+00
Os.41199.1.A1_at           5.2739191 8.565113e-01
Os.40007.1.S1_x_at         7.5399807 3.616511e-03
Os.10389.1.S1_at          14.6867288 4.923850e-15
OsAffx.20682.1.S1_at       8.1373271 6.054592e-07
Os.11272.1.S1_at          23.8014168 3.924763e-15
Os.9445.1.S1_at            3.7348991 9.999546e-01
Os.48215.1.A1_at           7.7983928 4.087535e-06
Os.8673.1.S1_at            3.0207054 1.000000e+00
Os.1465.1.S1_at            2.0149523 1.000000e+00
Os.53177.1.S1_s_at         1.7793677 1.000000e+00
OsAffx.28409.2.S1_s_at    10.3612406 3.066319e-09
Os.53439.1.S1_at           0.6084833 1.000000e+00
Os.12629.1.S1_at          14.4129696 1.303192e-14
Os.11555.1.S1_at          25.8168220 3.924763e-15
Os.11898.1.S1_at           2.4826799 1.000000e+00
Os.56232.1.S1_at           3.8937158 9.991598e-01
OsAffx.20930.1.S1_at       0.8633535 1.000000e+00
Os.47737.1.S1_at          16.3302129 3.924763e-15
OsAffx.17611.1.S1_at       9.6734983 1.982031e-13
Os.38638.3.S1_x_at        12.8598586 6.769140e-12
Os.52100.1.S1_at           1.1131520 1.000000e+00
Os.7770.1.S1_at            1.8907279 1.000000e+00
Os.9836.1.S1_at            3.9801545 9.996975e-01
Os.16744.1.S1_at           4.7786698 8.487769e-01
Os.51307.1.S1_at          20.7110943 3.924763e-15
OsAffx.26317.1.S2_at      22.0305966 3.924763e-15
OsAffx.2166.1.S1_at        2.1857363 1.000000e+00
Os.5621.1.S1_at            0.9228989 1.000000e+00
Os.11787.1.S1_at           5.9969109 4.598856e-01
Os.33625.4.S1_at           3.0034830 1.000000e+00
OsAffx.31756.4.S1_at      15.0711159 7.730811e-15
Os.50805.1.S1_at           3.8510661 9.990883e-01
OsAffx.29448.1.S1_at      14.6617885 6.172229e-15
Os.11801.1.S1_at          14.2877278 2.628469e-14
Os.47802.1.A1_at           5.7072394 4.220516e-01
OsAffx.18861.1.S1_at       7.0971611 2.546976e-03
Os.56150.1.S1_at           0.8081747 1.000000e+00
Os.12642.1.S1_at           1.7268489 1.000000e+00
Os.10469.1.S1_at           0.9095021 1.000000e+00
Os.55079.1.S1_at           3.0787385 1.000000e+00
Os.34174.1.S1_at           0.3669490 1.000000e+00
OsAffx.12433.1.S1_at      27.7546932 3.924763e-15
Os.50369.1.S1_at           4.3481856 9.997468e-01
OsAffx.15447.1.S1_at       4.2000430 9.984097e-01
Os.52619.1.S1_at           4.1465447 9.997280e-01
Os.17102.1.S1_at          23.1501308 3.924763e-15
OsAffx.30295.1.S1_at      14.6221147 3.930817e-14
Os.11800.1.S1_s_at         2.9667795 1.000000e+00
Os.10654.1.S1_s_at        14.1962193 9.320525e-15
Os.54579.1.S1_s_at        25.3524241 3.924763e-15
OsAffx.3569.1.S1_at        6.0476641 5.361096e-03
Os.55907.1.S1_at          23.7473267 3.924763e-15
Os.52058.1.S1_at           1.2809927 1.000000e+00
Os.57456.1.S1_x_at        14.5884072 3.924763e-15
Os.155.1.S1_a_at           3.1074127 1.000000e+00
Os.6345.1.S1_at            4.1667147 9.999843e-01
Os.11677.1.S1_x_at        17.8142127 3.924763e-15
OsAffx.8061.1.S1_at        5.3464361 9.574532e-01
OsAffx.13662.1.S1_at       1.1437257 1.000000e+00
Os.15199.1.S1_at           1.7023737 1.000000e+00
Os.31778.2.S1_x_at         8.1209786 1.074587e-10
Os.39994.1.S1_at           3.6638139 9.999987e-01
Os.50372.1.S1_at           0.5988341 1.000000e+00
Os.18381.1.S1_at           2.1229476 1.000000e+00
Os.11796.1.S1_at           0.8565061 1.000000e+00
OsAffx.19632.1.S1_at      21.0114521 3.924763e-15
Os.12767.1.S1_a_at         2.2435871 1.000000e+00
Os.34061.1.S1_a_at         1.6640753 1.000000e+00
Os.12239.1.S1_at           2.7383479 9.998392e-01
Os.49780.1.S1_x_at         8.9081440 4.946590e-08
OsAffx.7332.1.S1_at       26.5764293 3.924763e-15
Os.36162.1.S1_s_at         4.4839904 9.996754e-01
Os.44475.1.S1_at           4.8477924 9.998421e-01
Os.54555.1.S1_at           8.8579184 8.481117e-09
Os.15247.1.S1_s_at         5.4869830 6.652628e-01
Os.6683.1.S1_at            2.8223159 9.999822e-01
Os.56924.1.S1_at          13.6538406 3.157154e-14
OsAffx.15530.1.S1_at      13.3903402 5.452555e-14
Os.50290.1.S1_at          16.5680892 4.076179e-15
Os.57362.1.S1_at           0.6072699 1.000000e+00
Os.50883.1.S1_at          11.0202898 1.595949e-12
Os.12286.1.S1_at           0.6113191 1.000000e+00
Os.52536.1.S1_at           4.1784723 8.771183e-01
Os.6792.1.S1_at           19.3739461 4.565767e-15
Os.319.1.A1_at             0.5712339 1.000000e+00
Os.18933.1.S1_at           2.9011624 1.000000e+00
Os.4760.1.S1_at            4.9839090 8.800207e-01
OsAffx.30721.5.S1_at       3.5512708 9.654521e-01
OsAffx.15125.1.S1_at       1.2258645 1.000000e+00
Os.26802.1.S1_at           2.8366199 9.999924e-01
Os.11786.2.S1_at           0.4216017 1.000000e+00
Os.47413.1.S1_x_at        20.7647469 3.924763e-15
Os.24906.1.S1_at           6.0405242 7.271886e-01
Os.4715.1.S1_at            3.5633294 9.986820e-01
Os.534.2.S1_x_at          29.3394231 3.924763e-15
Os.8118.1.S1_at           13.8375147 4.076739e-14
Os.21319.1.S1_at           7.2655436 8.324607e-05
Os.23183.1.S1_at           6.8137328 2.742735e-03
Os.27659.1.S1_x_at         3.7958724 9.988934e-01
Os.23381.1.A1_at           3.7598265 9.924863e-01
Os.27759.1.S1_at           0.8403848 1.000000e+00
OsAffx.7934.1.S1_at       14.8967477 5.113116e-15
Os.54672.1.S1_at          21.9546358 3.924763e-15
Os.15471.1.S1_at           4.9815180 9.866503e-01
Os.31778.2.S1_at           7.8576443 6.312430e-10
Os.17652.1.S1_s_at         5.3451999 8.809924e-02
OsAffx.11963.1.S1_at       3.3562381 9.994822e-01
OsAffx.27299.1.S1_at       7.3177452 1.277019e-03
Os.5197.2.S1_x_at         24.1138798 3.924763e-15
Os.54653.1.S1_at          29.3483501 3.924763e-15
Os.16558.1.S1_at           4.2761367 9.178757e-01
Os.35154.1.S1_x_at        13.1390268 1.689185e-14
Os.54178.1.S1_at          14.6926780 9.675067e-15
Os.46710.2.S1_at           0.6703276 1.000000e+00
Os.54318.1.S1_at          12.4192818 7.498152e-13
OsAffx.13338.1.S1_at      15.2104167 5.513377e-15
Os.46869.1.A1_at           3.5398958 9.999986e-01
Os.44475.1.S1_x_at         5.1390746 9.993971e-01
Os.17997.1.S1_at           4.3357820 9.381721e-01
Os.32964.1.S1_at           5.8932980 1.523503e-01
Os.49294.1.S1_at           8.2512347 3.543660e-04
Os.26171.1.S1_at           2.1094495 1.000000e+00
Os.50450.1.S1_at           1.2661297 1.000000e+00
OsAffx.19332.1.S1_at      11.2772295 2.283514e-13
OsAffx.28727.1.S1_at      11.6200071 1.751912e-11
Os.16904.1.S1_at           0.2027055 1.000000e+00
Os.6825.1.S1_at            6.0206128 5.565109e-02
OsAffx.3504.1.S1_at        3.5963973 9.958297e-01
Os.4415.1.S1_at           14.3864880 1.887193e-14
Os.11834.1.S1_at           5.8554925 7.365318e-04
Os.37255.1.A1_at           4.7201659 2.286124e-01
Os.7674.1.S1_at            0.9328074 1.000000e+00
Os.56048.1.S1_s_at        21.0130052 3.924763e-15
OsAffx.15785.1.S1_at       6.0331725 1.823361e-01
Os.27624.1.S1_at           8.6121346 2.580783e-09
OsAffx.29866.1.S1_at      13.4739278 4.396463e-15
OsAffx.3569.1.S1_x_at      5.7401828 5.405393e-02
Os.6318.1.S1_at            6.3546932 2.143590e-01
OsAffx.27557.1.S1_at      16.0605985 3.924763e-15
Os.1479.1.S1_at            4.7652300 9.837880e-01
OsAffx.24515.1.S1_at      21.2392193 3.924763e-15
Os.51295.1.S1_at           3.1939346 9.999933e-01
Os.11255.1.S1_at          11.9491972 1.388961e-13
OsAffx.31756.4.S1_x_at    18.2811568 4.741483e-15
Os.49226.1.S1_at           0.8057054 1.000000e+00
OsAffx.17724.1.S1_at       5.6558757 8.532299e-01
OsAffx.3755.1.S1_at        0.3636347 1.000000e+00
Os.18664.1.S1_a_at         3.0250378 9.999401e-01
Os.33087.1.S1_at           7.0384624 3.269086e-03
Os.54146.1.S1_at          25.1207778 3.924763e-15
Os.11312.1.S1_s_at        15.5565386 4.076179e-15
OsAffx.4923.1.S1_at        7.4418789 1.179572e-03
OsAffx.29954.1.S1_at      12.5914005 5.365557e-12
OsAffx.27508.10.S1_s_at    4.1624959 9.767298e-01
Os.64.1.S1_at             12.2439511 2.053518e-13
OsAffx.30868.1.S1_at      20.3582211 4.076179e-15
Os.12986.1.S1_at           3.2454702 9.480189e-01
Os.52151.1.S1_at           7.3069216 1.842356e-06
OsAffx.31107.1.S1_at       1.1281550 1.000000e+00
Os.51491.1.S1_at           6.3082013 2.603852e-02
Os.11144.1.S1_at          10.7727219 1.819820e-10
Os.11308.1.S1_at          11.2420777 2.269090e-14
Os.40000.1.S1_at          23.0353729 3.924763e-15
Os.11251.1.S1_at          11.6893761 2.839699e-12
Os.5510.1.S1_at            4.5035190 8.893452e-01
Os.18830.1.S1_at           3.1981496 9.715531e-01
attr(,"class")
[1] "Statistical significance of gene connections"

dhga documentation built on May 2, 2019, 2:13 p.m.

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