disco.score: Calculate concordance score for differentially expressed...

In disco: Discordance and Concordance of Transcriptomic Responses

Description

For each pair of matched (orthologous) genes from an object of class mtchedOrtholog calculates the concordance / discordance score. The rationale is to formulate a metric allowing to compare heterologous data sets, e.g. data sets from different sources, technical platforms or even organisms.

Usage

disco.score(x)

Arguments

x	object of class matchedOrtholog

Details

\textrm{disco.score} := |logFC_1|\cdot|logFC_2|\cdot(|log_{10}(p_1)| + |log_{10}(p_2)|) \cdot \textrm{sign}(logFC_1) \cdot \textrm{sign}(logFC_2)

Where

logFC_1

log fold change of the expression change of the gene from the first data set

logFC_2

log fold change of the expression change of the gene from the second data set

p1

differential regulation p-value for the gene from the first data set

p2

differential regulation p-value for the gene from the second data set

Value

A numerical vector of the disco scores

Examples

data(orthologs)
orthologs$disco.score <- disco.score(orthologs)

disco documentation built on May 2, 2019, 9:40 a.m.