Data are from an experiment where isobutylalcohol was dissolved in a nutrient solution in which lettuce (Lactuca sativa) plants were grown. The plant biomass of the shoot was determined af 21 days.
A data frame with 14 observations on the following 2 variables.
a numeric vector of concentrations of isobutylalcohol (mg/l)
a numeric vector of biomass of shoot (g)
The data set illustrates hormesis, presence of a subtoxic stimulus at low concentrations.
van Ewijk, P. H. and Hoekstra, J. A. (1993) Calculation of the EC50 and its Confidence Interval When Subtoxic Stimulus Is Present, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 25, 25–32.
van Ewijk, P. H. and Hoekstra, J. A. (1994) Curvature Measures and Confidence Intervals for the Linear Logistic Model, Appl. Statist., 43, 477–487.
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## Look at data lettuce ## Monotonous dose-response model lettuce.m1 <- drm(weight~conc, data=lettuce, fct=LL.3()) plot(lettuce.m1, broken = TRUE) ## Model fit in van Ewijk and Hoekstra (1994) lettuce.m2 <- drm(weight~conc, data=lettuce, fct=BC.4()) modelFit(lettuce.m2) plot(lettuce.m2, add = TRUE, broken = TRUE, type = "none", lty = 2) ## Hormesis effect only slightly significant summary(lettuce.m2) ## Hormesis effect highly significant ## compare with t-test for the "f" parameter in the summary output) anova(lettuce.m1, lettuce.m2)