Description Usage Arguments Details Value Author(s) References See Also Examples
For single mixture data combination indices for effective doses as well as effects may be calculated and visualized.
1 2 3 4 5 6 |
mixProp |
a numeric value between 0 and 1 specifying the mixture proportion/ratio for the single mixture considered. |
modelList |
a list contained 3 models fits using |
EDvec |
a vector of numeric values between 0 and 100 (percentages) coresponding to the effect levels of interest. |
EDonly |
a logical value indicating whether or not only combination indices for effective doses should be calculated. |
effList |
a list returned by |
indAxis |
a character indicating whether effective doses ("ED") or effects ("EF") should be plotted. |
caRef |
a logical value indicating whether or not a reference line for concentration addition should be drawn. |
showPoints |
A logical value indicating whether or not estimated combination indices should be plotted. |
add |
a logical value specifying if the plot should be added to the existing plot. |
ylim |
a numeric vector of length 2 giving the range for the y axis. |
... |
additional graphical arguments. |
CIcomp
calculates the classical combination index for effective doses whereas CIcompX
calculates the combination index also for effects as proposed by
Martin-Betancor et al. (2015); for details and examples using "drc" see the supplementary material of this paper. The function plotFACI
may be used to visualize the
calculated combination index as a function of the fraction affected.
CIcomp
returns a matrix which one row per ED value. Columns contain
estimated combination indices, their standard errors and 95% confidence intervals,
p-value for testing CI=1, estimated ED values for the mixture data and assuming
concentration addition (CA) with corresponding standard errors.
CIcompX
returns similar output both for effective doses and effects (as a
list of matrices).
Christian Ritz and Ismael Rodea-Palomares
Martin-Betancor, K. and Ritz, C. and Fernandez-Pinas, F. and Leganes, F. and Rodea-Palomares, I. (2015) Defining an additivity framework for mixture research in inducible whole-cell biosensors, Scientific Reports 17200.
See mixture
for simultaneous modelling of several mixture ratios, but only at the ED50 level.
See also the help page for metals
.
1 2 3 4 5 6 7 8 9 10 | ## Fitting marginal models for the 2 pure substances
acidiq.0 <- drm(rgr ~ dose, data = subset(acidiq, pct == 999 | pct == 0), fct = LL.4())
acidiq.100 <- drm(rgr ~ dose, data = subset(acidiq, pct == 999 | pct == 100), fct = LL.4())
## Fitting model for single mixture with ratio 17:83
acidiq.17 <- drm(rgr ~ dose, data = subset(acidiq, pct == 17 | pct == 0), fct = LL.4())
## Calculation of combination indices based on ED10, ED20, ED50
CIcomp(0.17, list(acidiq.17, acidiq.0, acidiq.100), c(10, 20, 50))
## CI>1 significantly for ED10 and ED20, but not so for ED50
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