# Non Proportional Hazard effect

### Description

Generate the design matrix of spline basis for non proportional effect.

### Usage

1 2 3 4 5 6 7 8 9 10 |

### Arguments

`x` |
the predictor variable. |

`timevar` |
the time variable. |

`Spline` |
a character string specifying the type of spline basis. "b-spline" for B-spline basis, "tp-spline" for truncated power basis and "tpi-spline" for monotone (increasing) truncated power basis. |

`Knots.t` |
the internal breakpoints that define the spline used to estimate the NPH effect. By default there are none. |

`Degree.t` |
degree of splines which are considered. |

`Intercept.t` |
a logical value indicating whether intercept/first basis of spline should be considered. |

`Boundary.knots.t` |
range of time period which is analysed. By default it is the range of time variable. |

`Keep.duplicates.t` |
Should duplicate interior knots be kept or removed. Defaults is |

`outer.ok` |
logical indicating how are managed |

`...` |
not used |

### Details

`NPH`

is based on package `orthogonalsplinebasis`

### See Also

`NLL`

, and
`NPHNLL`

.

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