gastadj: Advanced Gastric Cancer dataset

In frailtypack: Shared, Joint (Generalized) Frailty Models; Surrogate Endpoints

Advanced Gastric Cancer dataset

Description

This meta-analysis was carried out by the GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research international Collaboration) group, using individual data on patients with curatively resected gastric cancer. Data from all published randomized trials, with a patient recruitment end date before 2004, and comparing adjuvant chemotherapy with surgery alone for resectable gastric cancers, were searched electronically. The candidate surrogate endpoint S was Desease-free survival time, defined as the time (in days) to relapse, second cancer or dead from any cause. The true endpoint T was the overall survival time, defined as the time (in days) from randomization to death of any cause or to the last follow-up.

Usage

data(gastadj)

Format

This data frame contains the following columns:

trialID

The trial in which the patient was treated

patientID

The identification number of a patient

trt

The treatment indicator, coded as 0 = Control and 1 = Experimental

timeS

The candidate surrogate (progression-free survival in days)

statusS

Censoring indicator for for Progression-free survival (0 = alive and progression-free, 1 = with progression or dead)

timeT

The true endpoint (overall survival time in days)

statusT

Censoring indicator for survival time (0 = alive, 1 = dead)

Source

Oba K, Paoletti X, Alberts S, Bang YJ, Benedetti J, Bleiberg H, Catalona P, Lordick F, Michiels S, Morita A, Okashi Y, Pignon JP, Rougier P, Sasako M, Sakamoto J, Sargent D, Shitara K, Van Cutsem E, Buyse M, Burzykowski T on behalf of the GASTRIC group (2013). Disease-Free Survival as a Surrogate for Overall Survival in Adjuvant Trials of Gastric Cancer: A Meta-Analysis. JNCI: Journal of the National Cancer Institute;105(21):1600-1607

frailtypack documentation built on Oct. 20, 2024, 1:08 a.m.