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#' Primary biliary cirrhosis data
#'
#' Primary biliary cirrhosis (PBC) data. PBC is a chronic liver disease which affects the bile
#' ducts of the liver, complications of which can ultimately lead to death. The longitudinal
#' profile of numerous biomarkers were observed for 312 patients at the Mayo Clinic between 1974
#' and 1984 with patients assigned to either the active (D-penicillamine, n=154 (50.6%)) or
#' placebo treatment arm (Murtaugh 1994). The data is publicly available in numerous places,
#' including \code{joineRML} and \code{survival}. The presence of many longitudinal biomarkers
#' of clinical interest as well as an event-time has lead to the PBC data becoming
#' widely used in literature.
#'
#' Nine longitudinal biomarkers exist with varying degrees of completeness in the data.
#'
#' @usage data('PBC')
#'
#' @format \code{data.frame} with 312 patients and 19 variables:
#' \describe{
#'
#' \item{\code{id}}{Subject identifier}
#' \item{\code{survtime}}{Survival time in years}
#' \item{\code{drug}}{Binary indicator covariate: was the patient assigned active
#' (\code{drug=1}) or placebo?}
#' \item{\code{sex}}{Binary indicator covariate: Takes value 1 if the subject is female, and zero
#' if male.}
#' \item{\code{time}}{Time of visit (0=baseline).}
#' \item{\code{ascites}}{Binary \emph{response} variable. Takes value 1 if accumulation of fluid
#' in abdomen ("ascites") present.}
#' \item{\code{hepatomegaly}}{Binary \emph{response} variable. Takes value 1 if enlarged liver
#' ("hepatomegaly") present.}
#' \item{\code{spiders}}{Binary \emph{response} variable. Takes value 1 if malformed blood
#' vessels in skin ("hepatomegaly") present.}
#' \item{\code{edema}}{Factor variable describing edema therapy, see
#' \code{\link[survival]{pbcseq}}.}
#' \item{\code{serBilir}}{Serum bilirubin (measured in mg/dl).}
#' \item{\code{serChol}}{Serum cholesterol (measured in mg/dl).}
#' \item{\code{album}}{Serum albumin (measured in mg/dl).}
#' \item{\code{alkaline}}{Alkaline phosphotase (measured in U/liter).}
#' \item{\code{SGOT}}{Aspartate aminotransferase (measured in U/liter).}
#' \item{\code{platelets}}{Platelet count per cubic ml/1000.}
#' \item{\code{histologic}}{Histologic stage of disease, see \code{\link[survival]{pbcseq}}.}
#' \item{\code{status}}{Survival status, \code{status=1} if the subject experienced mortality
#' and \code{=0} if censored.}
#' \item{\code{age}}{Standardised age at baseline visit.}
#'
#' }
#'
#' @keywords datasets
#'
#' @source \code{\link[survival]{pbcseq}}
#'
#' @references
#'
#' Murtaugh PA, Dickson ER, Van Dam GM, Malinchoc M, Grambsch PM, Langworthy AL, Gips CH. Primary
#' biliary cirrhosis: Prediction of short-term survival based on repeated patient visits.
#' \emph{Hepatology} 1994; \strong{20(1)}; 126-134.
#'
#'
"PBC"
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