f.nonconst: Function to compute the abundance of new or old RNA at time t...

In grandR: Comprehensive Analysis of Nucleotide Conversion Sequencing Data

Function to compute the abundance of new or old RNA at time t for non-constant rates.

Description

The standard mass action kinetics model of gene expression arises from the differential equation df/dt = s(t) - d(t) f(t), with s(t) being the synthesis rate at time t, d(t) the degradation rate at time t and f0=f(0) (the abundance at time 0). Here, both s and d have the following form s(t)=so+sf \cdot t^{se}.

Usage

f.nonconst(t, f0, s, d)

Arguments

t	time in h (can be a vector)
f0	the abundance at time t=0
s	the synthesis rate (see details)
d	the degradation rate (see details)

Details

Both rates can be either (i) a single number (constant rate), (ii) a data frame with names "offset", "factor" and "exponent" (for linear functions, see ComputeNonConstantParam; only one row allowed) or (iii) a unary function time->rate. Functions

Value

the RNA abundance at time t

See Also

f.nonconst.linear

grandR documentation built on April 4, 2025, 2:27 a.m.