View source: R/stratWO_data_frame.R

stratWO.data.frame | R Documentation |

Stratified win odds with adjustment

```
## S3 method for class 'data.frame'
stratWO(
x,
AVAL,
TRTP,
STRATA,
ref,
COVAR = NULL,
alpha = 0.05,
WOnull = 1,
...
)
```

`x` |
a data frame containing subject-level data. |

`AVAL` |
variable in the data with ordinal analysis values. |

`TRTP` |
the treatment variable in the data. |

`STRATA` |
a character variable for stratification. |

`ref` |
the reference treatment group. |

`COVAR` |
a numeric covariate. |

`alpha` |
the reference treatment group. |

`WOnull` |
the null hypothesis. The default is 1. |

`...` |
additional parameters. |

a data frame containing the following columns:

WO stratified (or adjusted/stratified) win odds.

LCL lower confidence limit for adjusted (or adjusted/stratified) WO.

UCL upper confidence limit for adjusted (or adjusted/stratified) WO.

SE standard error of the adjusted (or adjusted/stratified) win odds.

WOnull win odds of the null hypothesis (specified in the

`WOnull`

argument).alpha two-sided significance level for calculating the confidence interval (specified in the

`alpha`

argument).Pvalue p-value associated with testing the null hypothesis.

WP adjusted (or adjusted/stratified) win probability.

SE_WP standard error for the adjusted (or adjusted/stratified) win probability.

SD_WP standard deviation of the adjusted (or adjusted/stratified) win probability.

N total number of patients in the analysis.

Type "STRATIFIED" or "STRATIFIED/ADJUSTED" depending on whether

`COVAR`

is specified.

Gasparyan SB et al. (2021) "Adjusted win ratio with stratification: calculation methods and interpretation." Statistical Methods in Medical Research 30.2: 580-611. doi:10.1177/0962280220942558.

`stratWO()`

.

```
# Stratified win odds
res <- stratWO(x = KHCE, AVAL = "AVAL", TRTP = "TRTP",
STRATA = "STRATAN", ref = "P")
res
## Compare with the win odds in each stratum separately
lapply(split(KHCE, KHCE$STRATAN), calcWO, AVAL = "AVAL", TRTP = "TRTP", ref = "P")
# Stratified and adjusted win odds
res <- stratWO(x = KHCE, AVAL = "AVAL", COVAR = "EGFRBL",
TRTP = "TRTP", STRATA = "STRATAN", ref = "P")
res
```

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