hist_end: Adjust a design based on historical controls at the end of...

In hctrial: Using Historical Controls for Designing Phase II Clinical Trials

Description

Adjust a design based on historical controls at the end of the study using the covariate data of the patients accrued in stage 2.

Usage

hist_end(interim, stagetwo_data)

Arguments

interim	An design based on historical controls and adjusted at interim as returned by hist_interim().
stagetwo_data	A dataframe containing the relevant covariate data of the patients accrued in stage 2.

Value

A list returning the arguments of the function and the final design of the trial.

Examples

X <- abs(rnorm(1000, 0, 1))
Y <- rbinom(1000, 1, 1-exp(-X))
mydata <- data.frame("X" = X, "Y" = Y)
start <- hist_start(mydata, Y~X, c1 = 2)
n1 <- start$des_start[2]
X1 <- abs(rnorm(n1, 0, 1))
dataone <- data.frame("X" = X1)
interim <- hist_interim(start, dataone)
n2 <- interim$des_interim[4]
X2 <- abs(rnorm(n2, 0, 1))
datatwo <- data.frame("X" = X2)
hist_end(interim, datatwo)

hctrial documentation built on May 1, 2019, 10:53 p.m.