strat_start: Initializes a subspace stratified design before the start of...

In hctrial: Using Historical Controls for Designing Phase II Clinical Trials

Description

Initializes a subspace stratified design before the start of the study.

Usage

strat_start(p0_sub, p1_sub, distr_sub, alpha = 0.05, beta = 0.2)

Arguments

p0_sub	A vector, where the $i$-th entry corresponds to the response rate under the null for the $i$-th subtype.
p1_sub	A vector, where the $i$-th entry corresponds to the response rate under the alternative for the $i$-th subtype.
distr_sub	A vector, where the $i$-th entry corresponds to the prevalence of the $i$-th subtype in the population.
alpha	Specified type I error of the trial.
beta	Specified type II error of the trial.

Value

A list returning the arguments of the function and the preliminary design for starting the stratified trial.

Examples

p0_sub <- c(0.1, 0.3, 0.5)
p1_sub <- c(0.3, 0.5, 0.7)
distr_sub <- c(1/3, 1/3, 1/3)
strat_start(p0_sub, p1_sub, distr_sub)

hctrial documentation built on May 1, 2019, 10:53 p.m.