iChipRegionsB36: Autoimmune enriched regions as mapped on ImmunoChip

In humarray: Simplify Analysis and Annotation of Human Microarray Datasets

Description

Dataset. A consortium of 12 autoimmune diseases (Type 1 diabetes, Celiac disease, Multiple Sclerosis, Crohns Disease, Primary Billiary Cirrhosis, Psoriasis, Rheumatoid Arthritis, Systemic Lupus Erytematosus, Ulcerative Colitis, Ankylosing Spondylitis, Autoimmune Thyroid Disease, Juvenile Idiopathic Arthritis) created the ImmunoChip custom Illumina iSelect microarray in order to investigate known regions from GWAS associating with a p value < 5*10-8 with any of these diseases, using dense mapping of locii. This object specifies the boundaries of these regions, defined roughly as 0.1 centimorgan recombination distance either side of the top marker in each. The data is in the original build 36 coordinates as a GRanges object, but using functions in the humarray package can easily be converted to build 37, 38 or RangedData/data.frame.

Format

An object of class GRanges

References

Cortes and Brown, Promise and pitfalls of the Immunochip (2011). Arthritis Research and Therapy 2011, 13:101

See Also

conv.36.37 get.t1d.subset get.t1d.regions get.immunobase.snps

Examples

data(iChipRegionsB36)
prv(iChipRegionsB36)
iChipRegionsB37 <- conv.36.37(iChipRegionsB36) 

humarray documentation built on Nov. 20, 2017, 1:05 a.m.