Description Usage Arguments Details Value Side Effects See Also

View source: R/linkage.tests.q

Linkage tests, with and without covariates, for relative pair status groups Affected-Affected (AA), Unaffected-Unaffected (UU), or Affected-Unaffected (AU)

1 2 3 4 | ```
linkage.tests(y.mat, x.adj, ibdvar.lst, status.method, epsilon=1e-5)
linkage.tests.B0(y.mat, xvec, ibdvar.lst)
linkage.tests.pedloop(y.vec, x.adj, ibdvar.lst,
B0, concordant=TRUE, epsilon)
``` |

`y.mat ` |
matrix of ibd sharing statistics, which are the response in the regression model; each column represents one chromosome position. |

`y.vec ` |
vector of ibd sharing statistics (at one position), which are the response in the regression model (linkage.tests.pedloop only) |

`x.adj ` |
matrix of covariates, x, adjusted by c.scale. |

`xvec` |
the intercept column from x.adj, needed for pre-calculating Beta-0 |

`ibdvar.lst ` |
a list containing an element for each pedigree. The elements include ped.id, person1.id, person2.id, and the variance-covariance matrix of pairs of pairs of subjects. |

`status.method ` |
Character string indicating which relative pairs to apply the linkage tests: "AA", "UU", or "AU". |

`B0` |
The intercept in the regression model, ("beta-zero"). |

`concordant` |
logical; indicate whether to perform tests for linkage on concordant pairs (AA, UU), or discordant (AU). |

`epsilon` |
cutoff for singular values in generalized inverse (Ginv) |

The calculations for linkage tests require a pre-calculation of beta-zero (linkage.tests.B0) and then proceed with calculating the linkage test statistics for each position by looping over all pedigrees (linkage.tests.pedloop). Linkage tests can only be applied to one status group at a time, because the tests are restricted to whether the relative pairs are all concordant or discordant. Unexpected allele sharing can be detected when unconstrained linkage > constrained linkage tests. The method also returns z scores for pedigree-specific contributions to unexpected allele sharing indicated in linkage tests.

an object of class linkage.tests

none

`ibdreg`

,
`print.linkage.tests`

,
`plot.linkage.tests`

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