ra_data: Rheumatoid Arthritis Data

In mdhglm: Multivariate Double Hierarchical Generalized Linear Models

Description

The Rheumatoid Arthritis Patients rePort Onset Re-activation sTudy (RAPPORT study) is a longitudinal study that aims to identify an increase in disease activity by self-reported questionnaires. A cohort of 159 patients is followed throughout one year. Self-reported questionnaires are provided for patients every three months together with clinical evaluations of patients disease status. Health assessment questionnaires (HAQ) (20 questions from eight categories) and the Rheumatoid Arthritis Disease Activity Index (RADAI) (five items, e.g., todays disease activity in terms of swollen and tender joints) were used for patients to self-report their functional status. We use binarized versions of HAQ and RADAI, with cut-off points of 0.5 (HAQ) and 2.2 (RADAI). Lower values indicate disease stability, while higher values show increased disease activity. A clinical examination was recorded using the disease activity score with 28 joint counts (DAS28), which is a composite score that includes for example the swollen joints count. The DAS28 score varies between 0 and 10, and we assume Gaussian model to approximate its distribution. Information about DAS28, RADAI, and HAQ taken at months 0, 3, 6, 9, and 12 were considered in this example. The analysis include gender and baseline age of the patients as covariates.

Usage

data("ra_data")

Format

A data frame with 2089 observations on the following 13 variables.

id

subjects idenfier

sex

a factor for gender with levels M and V

age

age in year

yearsRA

years of RA

ethnic

a factor with levels Dutch and Other

edu

a factor with levels Master/Bachelor and Other than Master/Bachelor

X_NAME_

a factor with levels das0, das12, das3, das6, das9, haq0, haq12, haq3, haq6, haq9, radai0, radai12, radai3, radai6 and radai9

X_LABEL_

a factor with levels Das score (clinical) T=0, Das score (clinical) T=12, Das score (clinical) T=3, Das score (clinical) T=6, Das score (clinical) T=9, HAQ T=0, HAQ T=12, HAQ T=3, HAQ T=6, HAQ T=9, RADAI T=0, RADAI T=12, RADAI T=3, RADAI T=6 and RADAI T=9

outcome

outcome responses

outno

number for outcomes

outbin

outbin

outlabel

a factor with levels remission and stable

time

time in month

mdhglm documentation built on May 2, 2019, 5:52 a.m.