rats: Pregnant Rat Diet Experiment

In nlmixr: Nonlinear Mixed Effects Models in Population PK/PD

Pregnant Rat Diet Experiment

Description

16 pregnant rats have a control diet, and 16 have a chemically treated diet. The litter size for each rat is recorded after 4 and 21 days. This dataset is used in the SAS Probit-model with binomial data, and saved in the nlmixr package as rats.

Usage

rats

Format

A data frame with 32 rows and 6 columns

trt

Treatment; c= control diet; t=treated diet

m

Litter size after 4 days

x

Litter size after 21 days

x1

Indicator for trt=c

x2

Indicator for trt=t

ID

Rat ID

Source

https://support.sas.com/documentation/cdl/en/statug/63033/HTML/default/viewer.htm#statug_nlmixed_sect040.htm

References

Weil, C.S., 1970. Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis. Fd. Cosmet. Toxicol. 8, 177-182.

Williams, D.A., 1975. The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity. Biometrics 31, 949-952.

McCulloch, C. E. (1994), "Maximum Likelihood Variance Components Estimation for Binary Data," Journal of the American Statistical Association, 89, 330 - 335.

Ochi, Y. and Prentice, R. L. (1984), "Likelihood Inference in a Correlated Probit Regression Model," Biometrika, 71, 531-543.

See Also

Other nlmixr datasets: Bolus_1CPTMM, Bolus_1CPT, Bolus_2CPTMM, Bolus_2CPT, Infusion_1CPT, Oral_1CPT, Wang2007, pheno_sd, theo_md, theo_sd, warfarin

nlmixr documentation built on March 27, 2022, 5:05 p.m.