16 pregnant rats have a control diet, and 16 have a chemically treated diet. The litter size for each rat is recorded after 4 and 21 days. This dataset is used in the SAS Probit-model with binomial data, and saved in the nlmixr package as rats.
A data frame with 32 rows and 6 columns
Treatment; c= control diet; t=treated diet
Litter size after 4 days
Litter size after 21 days
Indicator for trt=c
Indicator for trt=t
Weil, C.S., 1970. Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis. Fd. Cosmet. Toxicol. 8, 177-182.
Williams, D.A., 1975. The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity. Biometrics 31, 949-952.
McCulloch, C. E. (1994), "Maximum Likelihood Variance Components Estimation for Binary Data," Journal of the American Statistical Association, 89, 330 - 335.
Ochi, Y. and Prentice, R. L. (1984), "Likelihood Inference in a Correlated Probit Regression Model," Biometrika, 71, 531-543.
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