addIndirect: Add an indirect response model to a PK model

In nlmixr2lib: A Model Library for 'nlmixr2'

Add an indirect response model to a PK model

Description

Add an indirect response model to a PK model

Usage

addIndirect(
  ui,
  stim = c("in", "out"),
  inhib = c("in", "out"),
  hill = FALSE,
  ek = "Ek",
  ik = "Ik",
  emax = "Emax",
  ec50 = "EC50",
  imax = "Imax",
  ic50 = "IC50",
  kin = "kin",
  kout = "kout",
  g = "g",
  cc = "Cc",
  R = "R",
  effect = "effect"
)

Arguments

ui	rxode2 model
stim	what type of stimulation indirect response model: - 'in': stimulation of input - 'out': stimulation of output
inhib	what type of inhibition indirect response model: - 'in': inhibition of input - 'out': inhibition of output
hill	Boolean stating if a hill sigmoid coefficient will be added
ek	simulation linear constant
ik	inhibition linear constant
emax	Emax parameter
ec50	EC50 parameter
imax	maximum inhibitory concentration
ic50	concentration where half of the Imax occurs
kin	this is the kin parameter name
kout	this is the kout parameter name
g	hill coefficient
cc	the concentration value
R	drug response compartment
effect	the effect variable that will be modeled

Value

pk model with indirect response model added

Author(s)

Matthew L. Fidler

See Also

Other Indirect response: addIndirectLin(), convertKinR0()

Examples

readModelDb("PK_2cmt_no_depot") |>
  addIndirect(stim="in",hill=TRUE)

readModelDb("PK_2cmt_no_depot") |>
  addIndirect(inhib="out", imax=1)

nlmixr2lib documentation built on Oct. 7, 2024, 5:08 p.m.