addIndirectLin: Add linear indirect response model

In nlmixr2lib: A Model Library for 'nlmixr2'

Add linear indirect response model

Description

Add linear indirect response model

Usage

addIndirectLin(
  ui,
  stim = c("in", "out"),
  inhib = c("in", "out"),
  ek = "Ek",
  ik = "Ik",
  kin = "kin",
  kout = "kout",
  cc = "Cc",
  R = "R",
  effect = "effect"
)

Arguments

ui	rxode2 model
stim	what type of stimulation indirect response model: - 'in': stimulation of input - 'out': stimulation of output
inhib	what type of inhibition indirect response model: - 'in': inhibition of input - 'out': inhibition of output
ek	simulation linear constant
ik	inhibition linear constant
kin	this is the kin parameter name
kout	this is the kout parameter name
cc	the concentration value
R	drug response compartment
effect	the effect variable that will be modeled

Value

model with linear indirect effect added

Note that while linear indirect effects are not common, it allows an easier hook to produce other standard effect curves like Emax/Imax, Hill, etc.

Author(s)

Matthew L. Fidler

See Also

Other Indirect response: addIndirect(), convertKinR0()

Examples

readModelDb("PK_2cmt_no_depot") |> addIndirectLin(stim="in")

readModelDb("PK_2cmt_no_depot") |> addIndirectLin(stim="out")

readModelDb("PK_2cmt_no_depot") |> addIndirectLin(inhib="in")

readModelDb("PK_2cmt_no_depot") |> addIndirectLin(inhib="out")

nlmixr2lib documentation built on Oct. 7, 2024, 5:08 p.m.