convertEmaxHill: Convert linear effect to Emax-Hill effect

In nlmixr2lib: A Model Library for 'nlmixr2'

Convert linear effect to Emax-Hill effect

Description

Convert linear effect to Emax-Hill effect

Usage

convertEmaxHill(
  ui,
  emax = "Emax",
  ec50 = "EC50",
  g = "g",
  imax = "Imax",
  ic50 = "IC50",
  ek = c("Ik", "Ek"),
  cc = c("Ec", "Cc")
)

Arguments

ui	rxode2 model
emax	Emax parameter
ec50	EC50 parameter
g	hill coefficient
imax	Imax parameter used when input model contains "Ik" instead of "Ek"
ic50	IC50 parameter used when input model contains "Ik" instead of "Ek"
ek	simulation linear constant
cc	the concentration value

Value

Model with the linear effect converted to an Emax effect

Author(s)

Matthew L. Fidler

Examples

readModelDb("PK_2cmt_no_depot") |>
  addIndirectLin(stim="in") |>
  convertEmaxHill()

# can also specify as emax=1

readModelDb("PK_2cmt_no_depot") |>
  addIndirectLin(stim="in") |>
  convertEmaxHill(emax=1)

nlmixr2lib documentation built on Oct. 7, 2024, 5:08 p.m.