Nothing
## ----setup, include = FALSE---------------------------------------------------
knitr::opts_chunk$set(
collapse = TRUE,
comment = "#>"
)
## ----eval=FALSE, fig.show='hold'----------------------------------------------
# install.packages("nph")
#
# # For dev version
# # install.packages("devtools")
# devtools::install_github("repo/nph")
## ----echo=FALSE, fig.height=3.5, fig.show='hold', fig.width=10, warning=FALSE, out.width='100%'----
library(nph)
times <- c(0, 5 * 365) # Time interval boundaries, in days
# Treatment group
t_resp <- 1 # There are no subgroups
B5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(18, nrow = 1)),
lambdaMat2 = m2r(matrix(11, nrow = 1)),
lambdaProgMat = m2r(matrix( 9, nrow = 1)),
p = t_resp,
timezero = FALSE, discrete_approximation = TRUE
)
# Control group
c_resp <- 1 # There are no subgroups
K5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(11, nrow = 1)),
lambdaMat2 = m2r(matrix( 9, nrow = 1)),
lambdaProgMat = m2r(matrix( 5, nrow = 1)),
p = c_resp,
timezero = TRUE, discrete_approximation = TRUE
)
plot_shhr(A = K5, B = B5, main = "Different disease progression by treatment")
## ----echo=FALSE, fig.height=3.5, fig.show='hold', fig.width=10, warning=FALSE, out.width='100%'----
times <- c(0, 100, 5 * 365) # Time interval boundaries, in days
# Treatment group
t_resp <- 1 # There are no subgroups
B5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(c(11, 18), nrow = 1)),
lambdaMat2 = m2r(matrix(c( 9, 11), nrow = 1)),
lambdaProgMat = m2r(matrix(c( 5, 9), nrow = 1)),
p = t_resp,
timezero = FALSE, discrete_approximation = TRUE
)
# Control group
c_resp <- 1
K5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(c(11, 11), nrow = 1)),
lambdaMat2 = m2r(matrix(c( 9, 9), nrow = 1)),
lambdaProgMat = m2r(matrix(c( 5, 5), nrow = 1)),
p = c_resp,
timezero = TRUE, discrete_approximation = TRUE
)
plot_shhr(K5, B5, main = "Different effect by time intervals")
## ----echo=FALSE, fig.height=3.5, fig.show='hold', fig.width=10, warning=FALSE, out.width='100%'----
times <- c(0, 5 * 365) # Time interval boundaries, in days
# Treatment group
t_resp <- c(.2, .8)
B5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(c(30,
18),nrow = 2)),
lambdaMat2 = m2r(matrix(c(20,
11),nrow = 2)),
lambdaProgMat = m2r(matrix(c(15,
9), nrow = 2)),
p = t_resp,
timezero = FALSE, discrete_approximation = TRUE
)
# Control group
c_resp <- 1
K5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(11,nrow = 1)),
lambdaMat2 = m2r(matrix(9, nrow = 1)),
lambdaProgMat = m2r(matrix(5, nrow = 1)),
p = c_resp,
timezero = TRUE, discrete_approximation = TRUE
)
plot_shhr(K5, B5, main = "Presence of subgroups with differential treatment effect")
## ----echo=FALSE, fig.height=4, fig.show='hold', fig.width=7, message=FALSE, warning=FALSE, out.width='75%', paged.print=TRUE----
times <- c(0, 5 * 365) # Time interval boundaries, in days
# Treatment group
t_resp <- 1 # There are no subgroups
B5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(18, nrow = 1)),
lambdaMat2 = m2r(matrix(11, nrow = 1)),
lambdaProgMat = m2r(matrix( 9, nrow = 1)),
p = t_resp,
timezero = FALSE, discrete_approximation = TRUE
)
# Control group
c_resp <- 1 # There are no subgroups
K5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(11, nrow = 1)),
lambdaMat2 = m2r(matrix( 9, nrow = 1)),
lambdaProgMat = m2r(matrix( 5, nrow = 1)),
p = c_resp,
timezero = TRUE, discrete_approximation = TRUE
)
plot_diagram(K5, B5, which = "Control")
## ----echo=FALSE, fig.align='center', fig.show='hold', fig.width=12.5, warning=FALSE, out.width='50%'----
knitr::include_graphics("lambdamat.png")
## ---- echo=TRUE, fig.show='hold', fig.width=12.5, warning=FALSE, out.width='100%'----
times <- c(0, 100, 5 * 365) # Time interval boundaries, in days
t_resp <- c(0.2, 0.8) #Proportion of subgroups
B5 <- pop_pchaz(
T = times,
lambdaMat1 = m2r(matrix(c(11, 30,
11, 18), byrow = TRUE, nrow = 2)),
lambdaMat2 = m2r(matrix(c( 9, 20,
9, 11), byrow = TRUE, nrow = 2)),
lambdaProgMat = m2r(matrix(c( 5, 15,
5, 9), byrow = TRUE, nrow = 2)),
p = t_resp, discrete_approximation = TRUE
)
## ---- echo=TRUE, fig.show='hold', fig.width=6, warning=FALSE, out.width='33%'----
plot(B5, main = "Survival function")
plot(B5, fun = "haz", main = "Hazard function")
plot(B5, fun = "cumhaz", main = "Cumulative Hazard function")
## -----------------------------------------------------------------------------
times <- c(0, 100, 5 * 365) # Time interval boundaries, in days
# Treatment group
B5 <- pop_pchaz(T = times,
lambdaMat1 = m2r(matrix(c(11, 30,
11, 18), byrow = TRUE, nrow = 2)),
lambdaMat2 = m2r(matrix(c( 9, 20,
9, 11), byrow = TRUE, nrow = 2)),
lambdaProgMat = m2r(matrix(c( 5, 15,
5, 9), byrow = TRUE, nrow = 2)),
p = c(0.2, 0.8),#Proportion of subgroups
discrete_approximation = TRUE
)
# Control group
K5 <- pop_pchaz(T = times,
lambdaMat1 = m2r(matrix(c(11, 11), nrow = 1)),
lambdaMat2 = m2r(matrix(c( 9, 9), nrow = 1)),
lambdaProgMat = m2r(matrix(c( 5, 5), nrow = 1)),
p = 1, discrete_approximation = TRUE
)
## -----------------------------------------------------------------------------
# Study set up and Simulation of a data set until interim analysis at 150 events
set.seed(15657)
dat <- sample_fun(K5, B5,
r0 = 0.5, # Allocation ratio
eventEnd = 450, # maximal number of events
lambdaRecr = 300 / 365, # recruitment rate per day (Poisson assumption)
lambdaCens = 0.013 / 365, # censoring rate per day (Exponential assumption)
maxRecrCalendarTime = 3 * 365,# Maximal duration of recruitment
maxCalendar = 4 * 365.25) # Maximal study duration
head(dat)
tail(dat)
## -----------------------------------------------------------------------------
logrank.test(time = dat$y,
event = dat$event,
group = dat$group,
# alternative = "greater",
rho = 1,
gamma = 0)
# survival::survdiff(formula = survival::Surv(time = dat$y, event = dat$event) ~ dat$group)
## -----------------------------------------------------------------------------
lrmt = logrank.maxtest(
time = dat$y,
event = dat$event,
group = dat$group,
rho = c(0, 0, 1, 1),
gamma = c(0, 1, 0, 1)
)
lrmt
## -----------------------------------------------------------------------------
lrmt$logrank.test[[1]]
lrmt$logrank.test[[2]]
lrmt$logrank.test[[3]]
lrmt$logrank.test[[4]]
Any scripts or data that you put into this service are public.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.