IntAUC: Calculate interval AUC

In pkr: Pharmacokinetics in R

Calculate interval AUC

Description

It calculates interval AUC

Usage

IntAUC(x, y, t1, t2, Res, down = "Linear")

Arguments

x	vector values of independent variable, usually time
y	vector values of dependent variable, usually concentration
t1	start time for AUC
t2	end time for AUC
Res	result from IndiNCA function
down	either of "Linear" or "Log" to indicate the way to calculate AUC

Details

This calculates an interval (partial) AUC (from t1 to t2) with the given series of x and y. If t1 and/or t2 cannot be found within x vector, it interpolates according to the down option.

Value

return interval AUC value (scalar)

Author(s)

Kyun-Seop Bae <[e-mail]>

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

AUC, Interpol

Examples

Res = sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], 
           dose=320, concUnit="mg/L")
IntAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], t1=0.5, t2=11, Res)

pkr documentation built on June 11, 2022, 9:05 a.m.