NCA0: NCA of SDTM data for single subject

In pkr: Pharmacokinetics in R

NCA of SDTM data for single subject

Description

This performs Noncompartmental Analysis(NCA) for one dosing record from the CDISC EX and PC domain.

Usage

NCA0(EX0, PC0, fit="Linear", excludeInfusion=TRUE, label="")

Arguments

EX0	One EX record: a named character vector, a one-row data.frame or a one-row matrix. It needs the names EXDOSE, EXDOSU, EXROUTE, EXSTDTC and EXENDTC.
PC0	The concentration records of that dosing interval, with the columns PCDTC, PCSTRESN and PCSTRESU
fit	either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC
excludeInfusion	when the administration is an infusion, estimate the terminal slope from post-infusion samples only; TRUE by default. See rNCA for what this changes.
label	identifier used only in warning messages

Details

The administration method is taken from EXROUTE first: an EXROUTE of "INTRAVENOUS" gives "Infusion" when EXENDTC is later than EXSTDTC and "Bolus" otherwise, and any other route gives "Extravascular". Time after dose is computed from EXSTDTC and negative values are set to zero, so a pre-dose sample is placed at time zero.

This calls sNCA. This is called by rNCA function.

Value

This returns a named character vector: AdmMethod, Dose, UnitDose, Dur, UnitTime, UnitConc, followed by the NCA parameters. Which parameters are present depends on the administration method.

Author(s)

Kyun-Seop Bae <[e-mail]>

See Also

help, rNCA, sNCA

pkr documentation built on July 30, 2026, 5:08 p.m.