calc_ss_3cmt: Calculate C(t) for a 3-compartment linear model at...

Description Usage Arguments Value Functions Author(s) References Examples

View source: R/calc_3cmt.R

Description

Calculate C(t) for a 3-compartment linear model at steady-state

Usage

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calc_ss_3cmt(tad, tau, dose, dur = NULL, tinf = NULL, ...)

calc_ss_3cmt_linear_bolus(tad, tau, dose, ...)

calc_ss_3cmt_linear_oral_1_lag(tad, tau, dose, ...)

calc_ss_3cmt_linear_infusion(tad, tau, dose, tinf, ...)

calc_ss_3cmt_linear_oral_0(tad, tau, dose, dur, ...)

calc_ss_3cmt_linear_oral_0_lag(tad, tau, dose, dur, ...)

calc_ss_3cmt_linear_oral_1(tad, tau, dose, ...)

Arguments

tad

Time after dose (h)

tau

Dosing interval (h)

dose

Dose

dur

Duration of zero-order absorption (h)

tinf

Duration of infusion (h)

...

Passed to 'calc_derived_3cpt()'

Value

Concentration of drug at requested time (t) at steady-state, given provided set of parameters and variables.

Functions

Author(s)

Justin Wilkins, justin.wilkins@occams.com

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Examples

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Ct <- calc_ss_3cmt_linear_bolus(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dose = 100, tau=24)
Ctrough <- calc_ss_3cmt_linear_oral_1_lag(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100, tau=24, tlag = 1.5)
Ct <- calc_ss_3cmt_linear_infusion(tad = 11.75, CL = 2.5, V1 = 20, V2 = 50,
    V3 = 100, Q2 = 0.5, Q3 = 0.05, dose = 1000, tinf=1, tau=24)
Ct <- calc_ss_3cmt_linear_oral_0(tad = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100, tau = 24)
Ct <- calc_ss_3cmt_linear_oral_0_lag(tad = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100, tau = 24, tlag = 1.5)
Ct <- calc_ss_3cmt_linear_oral_1(tad = 11.75, CL = 3.5, V1 = 20,
    V2 = 500, V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100, tau = 24)

Example output

Loading required package: MASS
Loading required package: stringr
Loading required package: magrittr
Loading required package: data.tree
Loading required package: DiagrammeR

pmxTools documentation built on Aug. 27, 2020, 1:10 a.m.