calc_sd_2cmt: Calculate C(t) for a 1-compartment linear model

Description Usage Arguments Value Functions Author(s) References Examples

View source: R/calc_2cmt.R

Description

Calculate C(t) for a 1-compartment linear model

Usage

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Arguments

t

Time after dose (h)

dose

Dose

dur

Duration of zero-order absorption (h)

tinf

Duration of infusion (h)

...

Passed to 'calc_derived_2cpt()'

Value

Concentration of drug at requested time (t) after a single dose, given provided set of parameters and variables.

Functions

Author(s)

Justin Wilkins, justin.wilkins@occams.com

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Examples

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Ct <- calc_sd_2cmt_linear_bolus(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5, dose = 10)
Ct <- calc_sd_2cmt_linear_oral_1_lag(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1, tlag = 2)
Ctrough <- calc_sd_2cmt_linear_infusion(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 10, tinf = 1)
Ctrough <- calc_sd_2cmt_linear_oral_0_lag(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1, tlag=2)
Ct <- calc_sd_2cmt_linear_oral_0_lag(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1, tlag=2)
Ct <- calc_sd_2cmt_linear_oral_1(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1)
Ct <- calc_sd_2cmt_linear_oral_0(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1)

pmxTools documentation built on Aug. 27, 2020, 1:10 a.m.