sample_sigma | R Documentation |
Sample from the multivariate normal distribution using the SIGMA variance-covariance matrix to generate new sets of simulated EPSILONs from NONMEM output.
sample_sigma(nmRun, n, seed)
nmRun |
Root filename for the NONMEM run (e.g. "run315"). |
n |
Number of samples required. |
seed |
Random seed. |
A data frame containing n
samples from the multivariate normal distribution, using
the estimated NONMEM SIGMA variance-covariance matrix. This provides n
sets of EPSILON estimates
suitable for simulation of new datasets.
Justin Wilkins, justin.wilkins@occams.com
NONMEM (https://www.iconplc.com/innovation/nonmem/)
## Not run: sigDist <- sample_sigma("run315", 5000, seed=740727) ## End(Not run)
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