minEffect.VSMc.logistic: Minimum detectable slope for mediator in logistic regression...

In powerMediation: Power/Sample Size Calculation for Mediation Analysis

Description

Calculate minimal detectable slope for mediator given sample size and power in logistic regression based on Vittinghoff, Sen and McCulloch's (2009) method.

Usage

minEffect.VSMc.logistic(n, 
                        power, 
                        sigma.m, 
                        p, 
                        corr.xm, 
                        alpha = 0.05, 
                        verbose = TRUE)

Arguments

n	sample size.
power	power for testing b_2=0 for the logistic regression \log(p_i/(1-p_i))=b0+b1 x_i + b2 m_i.
sigma.m	standard deviation of the mediator.
p	the marginal prevalence of the outcome.
corr.xm	correlation between the predictor x and the mediator m.
alpha	type I error rate.
verbose	logical. TRUE means printing minimum absolute detectable effect; FALSE means not printing minimum absolute detectable effect.

Details

The test is for testing the null hypothesis b_2=0 versus the alternative hypothesis b_2\neq 0 for the logistic regressions:

\log(p_i/(1-p_i))=b_0+b_1 x_i + b_2 m_i

Vittinghoff et al. (2009) showed that for the above logistic regression, testing the mediation effect is equivalent to testing the null hypothesis H_0: b_2=0 versus the alternative hypothesis H_a: b_2\neq 0, if the correlation corr.xm between the primary predictor and mediator is non-zero.

The full model is

\log(p_i/(1-p_i))=b_0+b_1 x_i + b_2 m_i

The reduced model is

\log(p_i/(1-p_i))=b_0+b_1 x_i

Vittinghoff et al. (2009) mentioned that if confounders need to be included in both the full and reduced models, the sample size/power calculation formula could be accommodated by redefining corr.xm as the multiple correlation of the mediator with the confounders as well as the predictor.

Value

b2	minimum absolute detectable effect.
res.uniroot	results of optimization to find the optimal sample size.

Note

The test is a two-sided test. For one-sided tests, please double the significance level. For example, you can set alpha=0.10 to obtain one-sided test at 5% significance level.

Author(s)

Weiliang Qiu [e-mail]

References

Vittinghoff, E. and Sen, S. and McCulloch, C.E.. Sample size calculations for evaluating mediation. Statistics In Medicine. 2009;28:541-557.

See Also

powerMediation.VSMc.logistic, ssMediation.VSMc.logistic

Examples

  # example in section 4 (page 545) of Vittinghoff et al. (2009).
  # minimum effect is log(1.5)= 0.4054651 

  minEffect.VSMc.logistic(n = 255, power = 0.8, sigma.m = 1, 
    p = 0.5, corr.xm = 0.5, alpha = 0.05, verbose = TRUE)

powerMediation documentation built on March 24, 2021, 1:06 a.m.