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precautionary: Safety Diagnostics for Dose-Escalation Trial Designs
Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020b), "Retrospective analysis of a fatal dose-finding trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design" <arXiv:2012.05301>.
Package details |
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| Author | David C. Norris [aut, cre, cph] (<https://orcid.org/0000-0001-9593-6343>), Markus Triska [ctb] |
| Maintainer | David C. Norris <david@precisionmethods.guru> |
| License | MIT + file LICENSE |
| Version | 0.2.6 |
| URL | https://github.com/dcnorris/precautionary |
| Package repository | View on CRAN |
| Installation |
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