Simulations produced by package
precautionary incorporate a ‘u_i’
latent toxicity tolerance that characterizes the toxic dose-response of each
simulated individual trial participant. In conjunction with an
‘ordinalizer’ function, these extra data enable questions to be asked
about trial safety, in terms of the probabilities of high-grade toxicities.
This function specializes the
An object of class c('precautionary','simulations')
An ordinalizer function
Additional parameters passed to the ordinalizer
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