stop_for_excess_toxicity_empiric: A supremely faster version of a function from 'dtpcrm' v0.1.1

In precautionary: Safety Diagnostics for Dose-Escalation Trial Designs

Description

Originally, the sampling in stats::rnorm() (see inline comments in code) consumed 53% of run-time in a 6-cohort VIOLA DTP. After this change, it doesn't even show up! More importantly, the consumption is now dominated by (at 75%) by the objective function 'f' in integrate().

Usage

stop_for_excess_toxicity_empiric(
  x,
  tox_lim,
  prob_cert,
  dose = 1,
  suppress_dose = TRUE
)

Arguments

x	A object of class mtd
tox_lim	Scalar upper threshold on estimated toxicity rate
prob_cert	Confidence level for threshold exceedance
dose	Integer scalar, the dose being considered
suppress_dose	Logical; if TRUE the MTD is set to NA when trial stop is recommended.

Value

The mtd object x, with stop decision annotated

Author(s)

Adapted by David C. Norris from original dtpcrm::stop_for_excess_toxicity_empiric

precautionary documentation built on Aug. 9, 2021, 9:14 a.m.