pssm.noninferiorityboundary: Non inferiority boundary as a function of the prior precision

In pssm: Piecewise Exponential Model for Time to Progression and Time from Progression to Death

Description

Generates a function of time for specified covariate values from a "pssm" object created by pssm that fits a joint proportional hazards and survival model using a piecewise exponential underlying hazard function

Usage

pssm.noninferiority.boundary(x,time,cov1,cov2,
                                       approximate=TRUE,alpha=0.05,iterations=50000)

Arguments

x	A pssm object created by pssm
time	The time point at which the treatments are to be compared
cov1	a a*b matrix of values of the b covariates affecting the time to progession
cov2	a matrix of values of the covariates affecting survival after progression with the same number of rows as cov1
approximate	If false it uses a metropolis hasting MCMC to calculate the upper boundary otherwise it uses a normal approximation for the posterior
alpha	The one sided alpha level of the bound
iterations	Number of MCMC iterations, only used if approximate=FALSE

Value

A function is returned that takes a vector input. For each element the function outputs the lower alpha confidence bound of the survival difference

Author(s)

David A. Schoenfeld

See Also

pssm-class, pssm-package, pssm.generate.data, pssm.object, pssm, pssm.simulate,

plot-methods, pssm.power

pssm documentation built on May 2, 2019, 11:12 a.m.