estimate_null_expected_count: Estimate expected null baseline count based on reference row...

In pvEBayes: Empirical Bayes Methods for Pharmacovigilance

Estimate expected null baseline count based on reference row and column

Description

This function estimates the expected null baseline count (E_{ij}) for each AE-drug combination under the assumption of independence between rows and columns. The expected count is calculated using a reference row (other AEs) and reference column (other drugs). This null baseline is typically used in empirical Bayes modeling of pvEBayes package for signal detection and estimation in spontaneous reporting system (SRS) data.

Usage

estimate_null_expected_count(contin_table)

Arguments

contin_table

an IxJ contingency table showing pairwise counts of adverse events for I AEs (along the rows) and J drugs (along the columns). The reference row "Other AEs" and the reference column "Other drugs" need to be the I-th row and J-th column respectively.

Details

This null value estimator is proposed by Tan et al. (2025).

Value

an nrow(contin_table) by ncol(contin_table) matrix.

References

Tan Y, Markatou M and Chakraborty S. Flexible Empirical Bayesian Approaches to Pharmacovigilance for Simultaneous Signal Detection and Signal Strength Estimation in Spontaneous Reporting Systems Data. arXiv preprint. 2025; arXiv:2502.09816.

Examples

estimate_null_expected_count(statin2025_44)

pvEBayes documentation built on Aug. 8, 2025, 6:13 p.m.