calc.ctmax: Calculate Cmax and Tmax

In qpNCA: Noncompartmental Pharmacokinetic Analysis by qPharmetra

Description

Calculates Cmax and Tmax from raw data for each PK curve defined using by.

Usage

calc.ctmax(x, by = character(0), timevar = "time", depvar = "dv")

Arguments

x	data.frame
by	column names in x indicating grouping variables
timevar	variable name containing the actual sampling time after dose
depvar	variable name containing the dependent variable (e.g., concentration)

Details

Input dataset can contain all uncorrected data, including LOQ; estimate first occurence of maximum concentration for each PK curve; if all concentrations are NA, sets Cmax and Tmax also to NA.

Value

A dataset with estimates for the Cmax (maximum concentration) and Tmax (time of first occurence of cmax) parameters: one observation per subject

Examples

example(est.thalf)
ctmax <- x %>% calc.ctmax(by = 'subject')
ctmax %>% head

qpNCA documentation built on Aug. 16, 2021, 5:08 p.m.