replicateBE: Average Bioequivalence with Expanding Limits (ABEL)

Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' and 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (Gulf Cooperation Council, South Africa: Cmax) - is implemented as well.

Package details

AuthorHelmut Schütz [aut, cre] (<>), Michael Tomashevskiy [ctb], Detlew Labes [ctb] (<>)
MaintainerHelmut Schütz <[email protected]>
LicenseGPL (>= 3)
Package repositoryView on CRAN
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replicateBE documentation built on Jan. 10, 2020, 1:08 a.m.