TRRT.RTTR.TTRR.RRTT | R Documentation |
Dataset from the public domain to be evaluated by method.A()
and/or method.B()
.
Reference Dataset 24
40 subjects (one completely missing).
Unbalanced (nine subjects in sequence TRRT and ten in each of the other three) and complete. Two outliers (subject 3 in sequence RTTR and subject 30 in sequence TTRR).
A data frame with 160 observations on the following 5 variables:
subject | a factor with 40 levels: 1, 2, ..., 932 |
period | a factor with 4 levels: 1, 2, 3, 4 |
sequence | a factor with 4 levels: TRRT, RTTR, TTRR, RRTT |
treatment | a factor with 2 levels: T, R |
PK | a numeric vector of pharmacokinetic responses acceptable for reference-scaling (here Cmax) |
Dataset | N | CVwR (%) | Evaluation |
rds24 | 39 | >30 | method.A() , method.B()
|
In software sequences and treatments are ranked in lexical order. Hence, executing str()
or summary()
will show sequence
as "RRTT", "RTTR", "TRRT", "TTRR"
and treatment
as "R", "T"
. In BE – by convention – sequences are ordered with T
first. The package follows this convention.
Dataset | Origin | Description |
rds24 | FDA, CDER | Cmax data of Drug 1. |
U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Bioequivalence Studies. Rockville, 1997. bioequivalence study files (archived 2017-07-23)
str(rds24) row <- c(13:16, 9:12, 1:4, 5:8) rds24[row, ] summary(rds24[2:5])
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