TR.RT.TT.RR: Reference Dataset for TR|RT|TT|RR Replicate Designs

In replicateBE: Average Bioequivalence with Expanding Limits (ABEL)

Reference Dataset for TR|RT|TT|RR Replicate Designs

Description

Dataset for Balaam’s design obtained by simulations to be evaluated by method.A(), method.B().

Usage

rds27

Format

• Reference Dataset 27 (rds27)
  312 subjects. Balanced (78 subjects in each of the four sequences) and incomplete (T of subject 111 missing in period 2 of sequence RT). No outliers.
  A data frame with 624 observations on the following 5 variables:

  rds27

  subject	a factor with 312 levels: 1, 2, ..., 18
  period	a factor with 2 levels: 1, 2
  sequence	a factor with 4 levels: TR, RT, TT, RR
  treatment	a factor with 2 levels: T, R
  PK	a numeric vector of pharmacokinetic responses acceptable for reference-scaling (generally Cmax)

Details

Dataset	N	CVwR (%)	Evaluation
rds27	312	>30	method.A(), method.B()

Note

In software sequences and treatments are ranked in lexical order. Hence, executing str() or summary() will show sequence as "RR", "RT", "TR", "TT" and treatment as "R", "T". In BE – by convention – sequences are ordered with T first. The package follows this convention.

Author(s)

Helmut Schütz (R-code for simulations by Detlew Labes)

Source

Dataset	Origin	Description
rds27	R	Simulated with CVwT = CVwR = 35%, CVbT = CVbR = 75%, GMR 0.90.

Examples

str(rds27)
row <- c(1:2, 157:158, 313:314, 469:470)
rds27[row, ]
summary(rds27[2:5])

replicateBE documentation built on May 3, 2022, 1:06 a.m.