catheter: Meta-analysis of antibacterial catheter coating

In rmeta: Meta-Analysis

Description

Data on the effectiveness of silver sulfadiazine coating on venous catheters for preventing bacterial colonisation of the catheter and bloodstream infection

Usage

data(catheter)

Format

A data.frame with 8 variables giving information about 16 controlled trials of antibacterial-coated venous catheters

Name :	Name of principal author
n.trt :	number of coated catheters
n.ctrl :	number of standard catheters
col.trt :	number of coated catheters colonised
	by bacteria
col.ctrl :	number of standard catheters colonised
	by bacteria
inf.trt :	number of coated catheters resulting in
	bloodstream infection
inf.ctrl :	number of standard catheters resulting in
	bloodstream infection
or :	Odds ratio

Source

Veenstra D et al (1998) "Efficacy of Antiseptic Impregnated Central Venous Catheters in Preventing Nosocomial Infections: A Meta-analysis" JAMA 281:261-267

Examples

library(rmeta)
data(catheter)
a <- meta.MH(n.trt, n.ctrl, col.trt, col.ctrl, data=catheter,
             names=Name, subset=c(13,6,5,3,7,12,4,11,1,8,10,2))
b <- meta.DSL(n.trt, n.ctrl, col.trt, col.ctrl, data=catheter,
              names=Name,subset=c(13,6,5,3,7,12,4,11,1,8,10,2))
a
b
summary(a)
summary(b)
plot(a)
plot(b)

Example output

Loading required package: grid
Warning message:
In meta.DSL(n.trt, n.ctrl, col.trt, col.ctrl, data = catheter, names = Name,  :
  Studies with 0/Inf statistic omitted
Fixed effects ( Mantel-Haenszel ) Meta-Analysis
Call: meta.MH(ntrt = n.trt, nctrl = n.ctrl, ptrt = col.trt, pctrl = col.ctrl, 
    names = Name, data = catheter, subset = c(13, 6, 5, 3, 7, 
        12, 4, 11, 1, 8, 10, 2))
Mantel-Haenszel OR =0.44    95% CI ( 0.36, 0.54 )
Test for heterogeneity: X^2( 10 ) = 25.36 ( p-value 0.0047 )
Random effects ( DerSimonian-Laird ) meta-analysis
Call: meta.DSL(ntrt = n.trt, nctrl = n.ctrl, ptrt = col.trt, pctrl = col.ctrl, 
    names = Name, data = catheter, subset = c(13, 6, 5, 3, 7, 
        12, 4, 11, 1, 8, 10, 2))
Summary OR= 0.4    95% CI ( 0.28, 0.57 )
Estimated random effects variance: 0.19 
Fixed effects ( Mantel-Haenszel ) meta-analysis
Call: meta.MH(ntrt = n.trt, nctrl = n.ctrl, ptrt = col.trt, pctrl = col.ctrl, 
    names = Name, data = catheter, subset = c(13, 6, 5, 3, 7, 
        12, 4, 11, 1, 8, 10, 2))
------------------------------------
             OR (lower  95% upper)
Tennenberg 0.22    0.10       0.49
Maki       0.49    0.29       0.82
vanHeerden 0.27    0.07       1.00
Hannan     0.83    0.40       1.72
Bach(a)     NaN    0.00        NaN
Bach(b)    0.11    0.02       0.49
Heard      0.60    0.38       0.95
Collins    0.10    0.02       0.41
Ciresi     0.69    0.34       1.42
Ramsay     0.58    0.37       0.92
Trazzera   0.47    0.23       0.94
George     0.12    0.04       0.33
------------------------------------
Mantel-Haenszel OR =0.44 95% CI ( 0.36,0.54 )
Test for heterogeneity: X^2( 10 ) = 25.36 ( p-value 0.0047 )
Random effects ( DerSimonian-Laird ) meta-analysis
Call: meta.DSL(ntrt = n.trt, nctrl = n.ctrl, ptrt = col.trt, pctrl = col.ctrl, 
    names = Name, data = catheter, subset = c(13, 6, 5, 3, 7, 
        12, 4, 11, 1, 8, 10, 2))
------------------------------------
             OR (lower  95% upper)
Tennenberg 0.22    0.10       0.49
Maki       0.49    0.29       0.82
vanHeerden 0.27    0.07       1.00
Hannan     0.83    0.40       1.72
Bach(a)     NaN    0.00        NaN
Bach(b)    0.11    0.02       0.49
Heard      0.60    0.38       0.95
Collins    0.10    0.02       0.41
Ciresi     0.69    0.34       1.42
Ramsay     0.58    0.37       0.92
Trazzera   0.47    0.23       0.94
George     0.12    0.04       0.33
------------------------------------
SummaryOR= 0.4  95% CI ( 0.28,0.57 )
Test for heterogeneity: X^2( 10 ) = 24.9 ( p-value 0.0055 )
Estimated random effects variance: 0.19 
(  1 studies with zero or infinite odds ratio omitted )

rmeta documentation built on May 2, 2019, 1:10 p.m.