seqCI: Confidence interval with the last Z-value for the group...

In sasLM: 'SAS' Linear Model

Confidence interval with the last Z-value for the group sequential design

Description

Confidence interval with given upper bounds, time of tests, the last Z-value, and confidence level.

Usage

  seqCI(bi, ti, Zval, conf.level=0.95)

Arguments

bi	upper bound z-values
ti	times for test. These should be [0, 1].
Zval	the last z-value from the observed data. This is not necessarily the planned final Z-value.
conf.level	confidence level

Details

It calculates confidence interval with given upper bounds, time of tests, the last Z-value, and confidence level. It assumes two-side test. mvtnorm::pmvt (with noncentrality) is better than pmvnorm in calculating power, sample size, and confidence interval. But, Lan-DeMets used multi-variate normal rather than multi-variate noncentral t distributionh. This function followed Lan-DeMets for the consistency with previous results. For the theoretical background, see the reference.

Value

confidence interval of Z-value for the given confidence level.

Author(s)

Kyun-Seop Bae [e-mail]

References

Reboussin DM, DeMets DL, Kim K, Lan KKG. Computations for group sequential boundaries using the Lan-DeMets function method. Controlled Clinical Trials. 2000;21:190-207.

Examples

  seqCI(bi = c(2.53, 2.61, 2.57, 2.47, 2.43, 2.38), 
        ti = c(.2292, .3333, .4375, .5833, .7083, .8333), Zval=2.82)

sasLM documentation built on Oct. 2, 2024, 9:06 a.m.