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sigminer: Extract, Analyze and Visualize Mutational Signatures for Genomic Variations
Genomic alterations including single nucleotide substitution, copy number alteration, etc. are the major force for cancer initialization and development. Due to the specificity of molecular lesions caused by genomic alterations, we can generate characteristic alteration spectra, called 'signature' (Wang, Shixiang, et al. (2021) <DOI:10.1371/journal.pgen.1009557> & Alexandrov, Ludmil B., et al. (2020) <DOI:10.1038/s41586-020-1943-3> & Steele Christopher D., et al. (2022) <DOI:10.1038/s41586-022-04738-6>). This package helps users to extract, analyze and visualize signatures from genomic alteration records, thus providing new insight into cancer study.
Getting started
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Package details |
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| Author | Shixiang Wang [aut, cre] (<https://orcid.org/0000-0001-9855-7357>), Ziyu Tao [aut] (<https://orcid.org/0000-0003-3272-1227>), Huimin Li [aut] (<https://orcid.org/0000-0003-1683-9057>), Tao Wu [aut] (<https://orcid.org/0000-0002-8999-9628>), Xue-Song Liu [aut, ctb] (<https://orcid.org/0000-0002-7736-0077>), Anand Mayakonda [ctb] |
| Maintainer | Shixiang Wang <w_shixiang@163.com> |
| License | MIT + file LICENSE |
| Version | 2.3.1 |
| URL | https://github.com/ShixiangWang/sigminer https://shixiangwang.github.io/sigminer/ https://shixiangwang.github.io/sigminer-book/ |
| Package repository | View on CRAN |
| Installation |
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