sigminer: Extract, Analyze and Visualize Mutational Signatures for Genomic Variations

Genomic alterations including single nucleotide substitution, copy number alteration, etc. are the major force for cancer initialization and development. Due to the specificity of molecular lesions caused by genomic alterations, we can generate characteristic alteration spectra, called 'signature' (Wang, Shixiang, et al. (2020) <DOI:10.1101/2020.04.27.20082404> & Alexandrov, Ludmil B., et al. (2020) <DOI:10.1038/s41586-020-1943-3>). This package helps users to extract, analyze and visualize signatures from genomic alteration records, thus providing new insight into cancer study.

Package details

AuthorShixiang Wang [aut, cre] (<https://orcid.org/0000-0001-9855-7357>), Ziyu Tao [aut] (<https://orcid.org/0000-0003-3272-1227>), Huimin Li [aut] (<https://orcid.org/0000-0003-1683-9057>), Tao Wu [aut] (<https://orcid.org/0000-0002-8999-9628>), Xue-Song Liu [aut, ctb] (<https://orcid.org/0000-0002-7736-0077>), Anand Mayakonda [ctb]
MaintainerShixiang Wang <w_shixiang@163.com>
LicenseMIT + file LICENSE
Version2.0.0
URL https://github.com/ShixiangWang/sigminer
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("sigminer")

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sigminer documentation built on April 1, 2021, 5:06 p.m.