The goal of 'snpsettest' is to provide simple tools that perform set-based association tests (e.g., gene-based association tests) using GWAS (genome-wide association study) summary statistics. A set-based association test in this package is based on the statistical model described in VEGAS (versatile gene-based association study), which combines the effects of a set of SNPs accounting for linkage disequilibrium between markers. This package uses a different approach from the original VEGAS implementation to compute set-level p values more efficiently, as described in <https://github.com/HimesGroup/snpsettest/wiki/Statistical-test-in-snpsettest>.
Package details |
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Author | Jaehyun Joo [aut, cre], Blanca Himes [aut] |
Maintainer | Jaehyun Joo <jaehyunjoo@outlook.com> |
License | GPL (>= 3) |
Version | 0.1.2 |
URL | https://github.com/HimesGroup/snpsettest |
Package repository | View on CRAN |
Installation |
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