N2finemapping: Simulated Fine-mapping Data with Two Effect Variables

Description Format References Examples

Description

This data set contains a genotype matrix for 574 individuals and 1,002 variables. The variables are genotypes after centering and scaling, and therefore retain the correlation structure of the original genotype data. Two of the variables have non-zero effects on the multivariate response. The response data are generated under a multivariate linear regression model. See Wang et al (2020) for details.

Format

N2finemapping is a list with the following elements:

X

Centered and scaled genotype data.

chrom

Chromomsome of the original data, in hg38 coordinates.

pos

Chromomosomal position of the original data, in hg38 coordinates. The information can be used to compare impact of using other genotype references of the same variables in susie_rss application.

true_coef

Simulated effect sizes.

residual_variance

Simulated residual covariance matrix.

Y

Simulated multivariate response.

allele_freq

Allele frequencies based on the original genotype data.

V

Suggested prior covariance matrix for effect sizes of the two non-zero effect variables.

References

G. Wang, A. Sarkar, P. Carbonetto and M. Stephens (2020). A simple new approach to variable selection in regression, with application to genetic fine-mapping. Journal of the Royal Statistical Society, Series B doi: 10.1101/501114.

Examples

1

susieR documentation built on June 2, 2021, 9:07 a.m.